What is the role of angiotensinogen in the RAAS?
Understand the Problem
The question is asking about the function of angiotensinogen in the Renin-Angiotensin-Aldosterone System (RAAS), specifically how it contributes to this hormonal system's function.
Answer
Angiotensinogen is the precursor in the RAAS that renin converts to angiotensin I.
Angiotensinogen is the substrate from which angiotensin I is derived in the RAAS. It is produced by the liver and is cleaved by renin to form angiotensin I, which is then further converted to angiotensin II, a crucial effector peptide in the RAAS.
Answer for screen readers
Angiotensinogen is the substrate from which angiotensin I is derived in the RAAS. It is produced by the liver and is cleaved by renin to form angiotensin I, which is then further converted to angiotensin II, a crucial effector peptide in the RAAS.
More Information
Angiotensinogen is a glycoprotein primarily produced in the liver and its conversion is the first step in activating the RAAS pathway, which is vital for maintaining blood pressure and fluid balance.
Tips
A common mistake is to confuse angiotensinogen with angiotensin peptides. It's important to remember that angiotensinogen is the precursor made by the liver.
Sources
- Angiotensinogen: More Than its Downstream Products: Evidence - jacc.org
- Renin Angiotensin Aldosterone System - ScienceDirect - sciencedirect.com
- Renin-angiotensin system - Wikipedia - en.wikipedia.org
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