What is the role of ACE in the hydrolysis of peptide bonds and its clinical significance?
Understand the Problem
The passage provides detailed information on the role of ACE (Angiotensin-Converting Enzyme) in the hydrolysis of peptide bonds, particularly related to angiotensin II and its implications in various clinical contexts, such as sarcoidosis and drug metabolism. It discusses the mechanisms and significance of ACE, macroenzymes, and drug-metabolizing enzymes in biological systems.
Answer
ACE hydrolyzes vasoactive peptides, regulates blood pressure, and maintains electrolyte homeostasis.
ACE hydrolyzes peptide bonds in vasoactive peptides like substance P, enkephalin, and neurotensin, contributing to blood pressure regulation and electrolyte homeostasis. Clinical significance includes its inactivation of peptides like bradykinin, influencing vasodilation and blood pressure maintenance.
Answer for screen readers
ACE hydrolyzes peptide bonds in vasoactive peptides like substance P, enkephalin, and neurotensin, contributing to blood pressure regulation and electrolyte homeostasis. Clinical significance includes its inactivation of peptides like bradykinin, influencing vasodilation and blood pressure maintenance.
More Information
ACE (Angiotensin-Converting-Enzyme) is significant in clinical settings for its role in managing blood pressure through the Renin-Angiotensin-Aldosterone System (RAAS). By hydrolyzing peptides, ACE helps regulate blood pressure and electrolyte balance.
Sources
- Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides ... - NCBI - ncbi.nlm.nih.gov
- Angiotensin Converting Enzyme (ACE)-Peptide Interactions - NCBI - ncbi.nlm.nih.gov
- Hydrolysis of Angiotensin Peptides by Human Angiotensin I ... - ahajournals.org
