What is the result of phospholipase C activation after receptor binding?
Understand the Problem
The question is asking about the biological effects that occur following the activation of phospholipase C after a receptor has been bound. It is looking for the result that correlates with this activation process.
Answer
Activation of PLC leads to PIP2 hydrolysis, forming IP3 (releases Ca2+) and DAG (activates PKC).
The final answer is that the activation of phospholipase C (PLC) after receptor binding leads to the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), resulting in the production of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 causes the release of calcium ions from intracellular stores, and DAG activates protein kinase C.
Answer for screen readers
The final answer is that the activation of phospholipase C (PLC) after receptor binding leads to the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), resulting in the production of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 causes the release of calcium ions from intracellular stores, and DAG activates protein kinase C.
More Information
Phospholipase C (PLC) plays a critical role in signaling pathways of various cells. The products of PLC activation, IP3, and DAG, are important for mobilizing intracellular calcium and activating protein kinase C, respectively, thus participating in various cellular responses, such as secretion, metabolism, and muscle contraction.
Tips
A common mistake is to confuse the downstream products of PLC activation. Remember that IP3 primarily increases intracellular calcium levels while DAG targets protein kinase pathways.
Sources
- Phospholipase C - an overview | ScienceDirect Topics - sciencedirect.com
- Phospholipase C in Living Cells : Activation, Inhibition, Ca 2+ ... - rupress.org
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