What is the primary mechanism through which tissue transglutaminase affects gluten peptides?
Understand the Problem
The question is asking about the specific role of tissue transglutaminase in relation to gluten peptides, particularly how it influences their properties and effects on the immune system.
Answer
Deamidation of specific glutamine residues.
The primary mechanism through which tissue transglutaminase affects gluten peptides is by deamidating specific glutamine residues, converting them to glutamic acid.
Answer for screen readers
The primary mechanism through which tissue transglutaminase affects gluten peptides is by deamidating specific glutamine residues, converting them to glutamic acid.
More Information
This deamidation process increases the immunogenicity of gluten peptides, leading to a more robust immune response and is a key factor in the pathogenesis of celiac disease.
Sources
- A role for tissue transglutaminase in α-gliadin peptide cytotoxicity - ncbi.nlm.nih.gov
- Interplay between Type 2 Transglutaminase (TG2), Gliadin Peptide ... - mdpi.com
- Interplay Between Gluten, HLA, Innate and Adaptive Immunity ... - frontiersin.org
AI-generated content may contain errors. Please verify critical information
