What is the primary effect of alpha 2 agonists like clonidine and methyldopa on sympathetic outflow?
Understand the Problem
The question is asking about the primary pharmacological effect of alpha 2 agonists, specifically clonidine and methyldopa, in relation to sympathetic nervous system activity. We are to determine how these drugs influence sympathetic outflow.
Answer
Inhibition of sympathetic outflow, reducing blood pressure.
The primary effect of alpha-2 agonists like clonidine and methyldopa is the inhibition of sympathetic outflow from the central nervous system, leading to decreased peripheral adrenergic signals and reduced blood pressure.
Answer for screen readers
The primary effect of alpha-2 agonists like clonidine and methyldopa is the inhibition of sympathetic outflow from the central nervous system, leading to decreased peripheral adrenergic signals and reduced blood pressure.
More Information
Alpha-2 agonists decrease the release of neurotransmitters like norepinephrine, leading to lower blood pressure and are commonly used to treat hypertension.
Tips
A common mistake is confusing alpha-2 receptors with alpha-1 receptors, which generally lead to vasoconstriction. Alpha-2 agonists instead decrease sympathetic output.
Sources
- Alpha-2 adrenergic agonists: Nursing pharmacology - Osmosis - osmosis.org
- Alpha-2 Adrenergic Receptor Agonists - DrugBank - go.drugbank.com
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