What is the primary characteristic of G protein-coupled receptors (GPCRs)?
Understand the Problem
The question is asking for the main feature of G protein-coupled receptors (GPCRs) from a list of options. We need to identify which option correctly describes their primary characteristic.
Answer
Presence of seven membrane-spanning α-helical segments.
The primary characteristic of G protein-coupled receptors (GPCRs) is the presence of seven membrane-spanning α-helical segments separated by alternating intracellular and extracellular loops.
Answer for screen readers
The primary characteristic of G protein-coupled receptors (GPCRs) is the presence of seven membrane-spanning α-helical segments separated by alternating intracellular and extracellular loops.
More Information
G protein-coupled receptors are found embedded in the cell membrane and are critical for signal transduction, interpreting signals from outside the cell to trigger internal responses.
Tips
A common mistake is confusing the functional role (signal transduction through G proteins) with the structural characteristic (seven α-helices).
Sources
- PMC - NIH - pmc.ncbi.nlm.nih.gov
- G protein-coupled receptor - Wikipedia - en.wikipedia.org
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