What is the pathogenesis of anemia of chronic disorders (ACD)?
Understand the Problem
The question appears to be asking about the pathogenesis of anemia of chronic disorders (ACD), including the factors involved such as chronic disease, pro-inflammatory cytokines, hepcidin production, and functional iron deficiency. This implies a need for a detailed explanation of the mechanisms behind ACD.
Answer
ACD pathogenesis involves inflammation-induced cytokines, increased hepcidin, and impaired iron utilization.
The pathogenesis of anemia of chronic disorders (ACD) involves a chronic inflammatory state causing the release of cytokines (e.g., IL-6), increased hepcidin production, and functional iron deficiency by impairing iron release from macrophages and reducing intestinal absorption.
Answer for screen readers
The pathogenesis of anemia of chronic disorders (ACD) involves a chronic inflammatory state causing the release of cytokines (e.g., IL-6), increased hepcidin production, and functional iron deficiency by impairing iron release from macrophages and reducing intestinal absorption.
More Information
Kepcidin plays a key role by regulating iron homeostasis, contributing to the low serum iron seen in ACD despite normal or high ferritin levels, due to sequestration of iron in macrophages.
Tips
A common mistake is to confuse ACD with iron deficiency anemia; both involve low serum iron, but ferritin is typically normal or elevated in ACD.
Sources
- The web page with info on - Example Source - merckmanuals.com
- Pathogenesis and treatment of anaemia of chronic disease - PubMed - pubmed.ncbi.nlm.nih.gov
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