What is the most appropriate antiretroviral to initiate in a 35-year-old male recently diagnosed with HIV, with a CD4+ cell count of 300 cells/mm³ and a viral load of 40,000 copies... What is the most appropriate antiretroviral to initiate in a 35-year-old male recently diagnosed with HIV, with a CD4+ cell count of 300 cells/mm³ and a viral load of 40,000 copies/mL?
Understand the Problem
The question is asking for the most appropriate antiretroviral treatment for a newly diagnosed HIV patient, considering his specific lab results and medical history.
Answer
Abacavir/lamivudine/dolutegravir
The most appropriate antiretroviral to initiate in this patient is Abacavir/lamivudine/dolutegravir.
Answer for screen readers
The most appropriate antiretroviral to initiate in this patient is Abacavir/lamivudine/dolutegravir.
More Information
Abacavir/lamivudine/dolutegravir is a common first-line regimen recommended for its effectiveness and tolerability. It combines an integrase inhibitor (dolutegravir) with two nucleoside reverse transcriptase inhibitors (abacavir and lamivudine).
Tips
Ensure that the patient is screened for HLA-B*5701 before using abacavir to avoid hypersensitivity reactions.
Sources
- ART and Initial Therapy - HIV Clinical Guidelines - hiv.uw.edu
- Plasma HIV-1 RNA and CD4 Monitoring - NIH - clinicalinfo.hiv.gov
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