What is the effect of early Sxl protein absence in male Drosophila regarding sex-lethal mRNA splicing?
Understand the Problem
The question is asking about the consequences of the absence of early Sxl protein in male Drosophila, specifically related to the splicing of sex-lethal mRNA. This involves understanding the mechanisms of gene regulation and protein production in relation to sex differentiation in fruit flies.
Answer
Absence of early Sxl protein results in male-specific mRNA splicing in Drosophila.
In the absence of the early Sxl protein in male Drosophila, mRNA splicing results in the inclusion of male-specific exons, leading to the production of mRNAs necessary for male development. Sxl protein controls sex determination by regulating mRNA splicing.
Answer for screen readers
In the absence of the early Sxl protein in male Drosophila, mRNA splicing results in the inclusion of male-specific exons, leading to the production of mRNAs necessary for male development. Sxl protein controls sex determination by regulating mRNA splicing.
More Information
The Sex-lethal (Sxl) protein acts as a key regulator in sex determination in Drosophila, mainly by controlling the splicing of its own mRNA and that of other genes involved in the sex determination pathway.
Tips
A common mistake is assuming that Sxl is only involved in female pathways. Even in males, its absence directs typical male development paths.
Sources
- Promiscuity in post‐transcriptional control of gene expression - febs.onlinelibrary.wiley.com
- Distinct mechanisms of splicing regulation in vivo by the Drosophila... - pnas.org
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