What is gain-of-function mutation?
Understand the Problem
The question is asking for a definition or explanation of what a gain-of-function mutation is, which typically refers to mutations that enhance the activity or function of a gene or protein.
Answer
A mutation causing new functions or increased activity in a gene product.
A gain-of-function mutation causes an altered gene product to have new molecular functions or an increase in normal activity, potentially changing the organism's characteristics.
Answer for screen readers
A gain-of-function mutation causes an altered gene product to have new molecular functions or an increase in normal activity, potentially changing the organism's characteristics.
More Information
Gain-of-function mutations play a vital role in evolutionary biology and medical research by enabling organisms to develop new traits or adapt better to their environments.
Tips
A common misconception is that all mutations are harmful, but gain-of-function mutations can be beneficial or neutral.
Sources
- Gain of Function Mutation - an overview | ScienceDirect Topics - sciencedirect.com
- Gain-of-Function Mutation - an overview | ScienceDirect Topics - sciencedirect.com
- Glossary: Gain-of-function Mutation - Mouse Genome Informatics - informatics.jax.org
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