What does the reaction mechanism involving PLP utilize to facilitate the transfer of amino groups?
Understand the Problem
The question is asking about the specific mechanisms involved in the biochemical reaction facilitated by pyridoxal phosphate (PLP), specifically how it aids in the transfer of amino groups. The user needs to determine which of the provided options correctly describes these mechanisms.
Answer
PLP facilitates amino group transfer via transamination using a ping-pong bi-bi mechanism.
The reaction mechanism involving Pyridoxal Phosphate (PLP) facilitates the transfer of amino groups through a process called transamination, using a ping-pong bi-bi mechanism. This involves two half-reactions: 1) the oxidative deamination of an amino group donor and 2) the reductive amination of an acceptor ketone.
Answer for screen readers
The reaction mechanism involving Pyridoxal Phosphate (PLP) facilitates the transfer of amino groups through a process called transamination, using a ping-pong bi-bi mechanism. This involves two half-reactions: 1) the oxidative deamination of an amino group donor and 2) the reductive amination of an acceptor ketone.
More Information
Pyridoxal Phosphate (PLP) acts as a coenzyme in transamination reactions. PLP forms a Schiff base with the amino group donor, transferring the amino group to an acceptor molecule. This mechanism is crucial in amino acid metabolism, facilitating the synthesis and degradation of amino acids.
Tips
A common mistake is misunderstanding the 'ping-pong' mechanism. Remember, it involves sequential reactions: first handling the donor, then the acceptor.
Sources
- Pyridoxal phosphate - Wikipedia - en.wikipedia.org
- Pyridoxal 5 Phosphate - an overview | ScienceDirect Topics - sciencedirect.com
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