What characterizes the molecular control of skeletal formation? A. Hox genes promote the formation of chondroblasts from mesenchymal cells; B. BMP is responsible for the overall de... What characterizes the molecular control of skeletal formation? A. Hox genes promote the formation of chondroblasts from mesenchymal cells; B. BMP is responsible for the overall development of the skeleton. C. BMP-4 is the only morphogenetic factor that promotes embryonic bone development; D. Cbfa 1 promotes the formation of osteoblasts from mesenchymal cells; What is true about limb development? A. Initially, leg development ends only then does horizontal flexion appear in the arms; B. All statements are false. C. Wnt7-a indirectly stimulates the development of the dorsal limb plane; D. On the 33rd day of development, areas of radial necrosis appear between the fingers; E. Leg development ends on the 60th day;
Understand the Problem
The question is asking about the molecular mechanisms involved in skeletal formation and limb development, specifically focusing on various factors such as Hox genes and BMP. The aim is to identify correct statements related to these processes.
Answer
D: Cbfa 1 promotes the formation of osteoblasts; C: Wnt7-a stimulates dorsal limb plane development.
The correct statement about skeletal formation is D: Cbfa 1 promotes the formation of osteoblasts from mesenchymal cells. For limb development, the true statement is C: Wnt7-a indirectly stimulates the development of the dorsal limb plane.
Answer for screen readers
The correct statement about skeletal formation is D: Cbfa 1 promotes the formation of osteoblasts from mesenchymal cells. For limb development, the true statement is C: Wnt7-a indirectly stimulates the development of the dorsal limb plane.
More Information
Cbfa1, also known as Runx2, is crucial for osteoblast differentiation and bone formation, whereas Wnt7-a plays a role in establishing the dorsal-ventral axis in limb development.
Tips
A common mistake is to assume BMP-4 is the only factor in bone development. Multiple signaling pathways influence these processes.
Sources
- Regulation of Osteoblast Differentiation Mediated by Bone - academic.oup.com
- Mechanisms of bone development and repair - PMC - NCBI - ncbi.nlm.nih.gov
- Morphogenetic and Regulatory Mechanisms During Developmental Biology - liebertpub.com
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