What are the structural features and functions of nuclear receptors as shown in the image?
Understand the Problem
The question is asking for an understanding of the structural and functional aspects of nuclear receptors, particularly focusing on their DNA binding domains and transcriptional activities based on the provided image.
Answer
Modular structure with six domains: A/B, C (DBD), D (Hinge), E (LBD), F. Functions: DNA-binding, ligand-binding, dimerization, transcription regulation.
Nuclear receptors have a modular structure with six functional domains, including an N-terminal domain (A/B), DNA-binding domain (DBD, C), Hinge region (D), Ligand-binding domain (LBD, E), and a C-terminal domain (F). Their functions include DNA-binding, ligand-binding, dimerization, and transcription regulation.
Answer for screen readers
Nuclear receptors have a modular structure with six functional domains, including an N-terminal domain (A/B), DNA-binding domain (DBD, C), Hinge region (D), Ligand-binding domain (LBD, E), and a C-terminal domain (F). Their functions include DNA-binding, ligand-binding, dimerization, and transcription regulation.
More Information
Nuclear receptors are crucial transcription factors that respond to small lipophilic molecules, regulating key biological processes including development, metabolism, and reproduction.
Tips
A common mistake is confusing the domains and their respective functions; remember the specific roles of the DBD and LBD.
Sources
- Structure and Function of the Nuclear Receptor Superfamily ... - NCBI - ncbi.nlm.nih.gov
- Nuclear Receptor - an overview | ScienceDirect Topics - sciencedirect.com
- Nuclear Receptor - an overview | ScienceDirect Topics - sciencedirect.com
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