What are the processes involved in endogenous and exogenous antigen processing in T cell activation?
Understand the Problem
The question appears to be focused on the processes involved in endogenous and exogenous antigen processing in the context of T cell activation. It outlines sources of antigens and the steps involved in the processing pathways while emphasizing key roles in immune defense. The likely intention is to clarify biological mechanisms relevant to immunology.
Answer
Endogenous (MHC I) for CD8+ T cells; Exogenous (MHC II) for CD4+ T cells.
Endogenous antigen processing (MHC Class I) involves intracellular proteins being degraded, presented on the cell surface, and recognized by CD8+ T cells. Exogenous antigen processing (MHC Class II) involves engulfing pathogens, degrading them in lysosomes, and presenting them to CD4+ T cells.
Answer for screen readers
Endogenous antigen processing (MHC Class I) involves intracellular proteins being degraded, presented on the cell surface, and recognized by CD8+ T cells. Exogenous antigen processing (MHC Class II) involves engulfing pathogens, degrading them in lysosomes, and presenting them to CD4+ T cells.
More Information
Endogenous processing is crucial for defenses against viruses and tumors, while exogenous processing helps fend off bacteria and parasites.
Tips
A common mistake is confusing which type of T cell is activated by which pathway. Remember: MHC I activates CD8+ and MHC II activates CD4+.
Sources
- Antigen Processing and Presentation | British Society for Immunology - immunology.org
- Antigen processing - Wikipedia - en.wikipedia.org
- Endogenous Antigen | Definition, Sources & Processing - Study.com - study.com
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