What are the indications, mechanism of action, side effects, contraindications, and drug interactions for sodium stibogluconate and miltefosine?
Understand the Problem
The question relates to the medications sodium stibogluconate and miltefosine, detailing their uses, indications, mechanisms of action, side effects, contraindications, and interactions.
Answer
Sodium stibogluconate treats leishmaniasis with side effects like pancreatitis. Miltefosine disrupts parasite membranes, causing GI issues. Both may interact with nephrotoxic/hepatotoxic drugs.
Sodium stibogluconate is used to treat leishmaniasis and works by inhibiting energy metabolism in parasites, with side effects like pancreatitis and liver toxicity. Miltefosine treats leishmaniasis by disrupting parasite cell membranes, causing gastrointestinal issues. Both can interact with nephrotoxic/hepatotoxic drugs.
Answer for screen readers
Sodium stibogluconate is used to treat leishmaniasis and works by inhibiting energy metabolism in parasites, with side effects like pancreatitis and liver toxicity. Miltefosine treats leishmaniasis by disrupting parasite cell membranes, causing gastrointestinal issues. Both can interact with nephrotoxic/hepatotoxic drugs.
More Information
Sodium stibogluconate inhibits DNA functions in parasites, while miltefosine disrupts membranes. Both are primarily used for leishmaniasis treatment.
Tips
Patients with severe renal or hepatic dysfunction should avoid these drugs due to increased risk of toxicity.
Sources
- Sodium Stibogluconate - an overview | ScienceDirect Topics - sciencedirect.com
- Miltefosine: Uses, Interactions, Mechanism of Action - DrugBank - go.drugbank.com
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