What are the actions of PGE2 at different receptors?
Understand the Problem
The image provides information about the actions of PGE2 at various receptors, detailing its effects on bronchial and gastrointestinal smooth muscle, gastric secretion, and more. It likely seeks clarification or discussion on these biological processes.
Answer
EP1: muscle contraction; EP2: bronchodilatation, vasodilatation; EP3: muscle contraction, secretion inhibition; EP4: similar to EP2.
The actions of PGE2 at its receptors are: EP1 - contraction of bronchial and GI smooth muscle; EP2 - bronchodilatation, vasodilatation, stimulation of intestinal fluid secretion, and GI smooth muscle relaxation; EP3 - intestinal smooth muscle contraction, gastric secretion inhibition, lipolysis inhibition, autonomic neurotransmitter release inhibition, pregnant uterine contraction; EP4 - similar to EP2 effects, includes vascular relaxation, cervical ripening.
Answer for screen readers
The actions of PGE2 at its receptors are: EP1 - contraction of bronchial and GI smooth muscle; EP2 - bronchodilatation, vasodilatation, stimulation of intestinal fluid secretion, and GI smooth muscle relaxation; EP3 - intestinal smooth muscle contraction, gastric secretion inhibition, lipolysis inhibition, autonomic neurotransmitter release inhibition, pregnant uterine contraction; EP4 - similar to EP2 effects, includes vascular relaxation, cervical ripening.
More Information
PGE2's actions vary depending on the receptor subtype it binds to, highlighting its role in inflammation, smooth muscle activity, and immune modulation.
Tips
A common mistake is confusing EP2 and EP4 receptor actions; both have similar effects.
Sources
- Prostaglandin E Receptor - ScienceDirect Topics - sciencedirect.com
- Prostaglandin E2 receptor - Wikipedia - en.wikipedia.org
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