The Lewis (007) System. The Lewis blood group system is unique because the Lewis antigens are not intrinsic to RBCs but are on type 1 glycosphingolipids that are passively adsorbed... The Lewis (007) System. The Lewis blood group system is unique because the Lewis antigens are not intrinsic to RBCs but are on type 1 glycosphingolipids that are passively adsorbed onto the RBC membrane from the plasma. It covers the history, prevalence, and biochemistry of the Lewis blood group system.
Understand the Problem
The question provides a detailed explanation of the Lewis blood group system, discussing its antigens, genetics, and biochemical interactions. It describes how Lewis antigens are not intrinsic to red blood cells and their relation to other blood group systems. This is largely informative and would be relevant for someone studying human blood groups or transfusion medicine.
Answer
Lewis antigens are not intrinsic to RBCs but adsorbed from plasma.
The Lewis blood group system is unique because its antigens are not intrinsic to red blood cells but are passively adsorbed onto their membrane from the plasma. They are located on type 1 glycosphingolipids and come in forms such as Lea and Leb.
Answer for screen readers
The Lewis blood group system is unique because its antigens are not intrinsic to red blood cells but are passively adsorbed onto their membrane from the plasma. They are located on type 1 glycosphingolipids and come in forms such as Lea and Leb.
More Information
Lewis blood group antigens are associated with genes on chromosome 19, including the FUT3 (Lewis gene) and FUT2 (Secretor gene), affecting their expression.
Tips
A common mistake is assuming the antigens are produced by the RBCs themselves; they are actually adsorbed from the plasma.
Sources
- Case series investigation on the Lewis system antibodies - pmc.ncbi.nlm.nih.gov
- The Lewis Blood Group System and Secretor Status - thebiomedicalscientist.net
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