Purine and pyrimidine bases can also be synthesized by?
Understand the Problem
The question is asking about the synthesis of purine and pyrimidine bases, which relates to biochemistry and molecular biology. Specifically, it is likely inquiring about alternative pathways or methods for the biosynthesis of these nucleotide components.
Answer
De novo synthesis using PRPP and the salvage pathway.
Purine and pyrimidine bases can be synthesized by the de novo pathway using simple molecules like CO2, amino acids, and tetrahydrofolate with the help of the 5-phosphoribosyl-1-pyrophosphate (PRPP) enzyme. They can also be synthesized through the salvage pathway using preformed bases or nucleosides.
Answer for screen readers
Purine and pyrimidine bases can be synthesized by the de novo pathway using simple molecules like CO2, amino acids, and tetrahydrofolate with the help of the 5-phosphoribosyl-1-pyrophosphate (PRPP) enzyme. They can also be synthesized through the salvage pathway using preformed bases or nucleosides.
More Information
Purine and pyrimidine nucleotides are essential for DNA and RNA synthesis and can be formed anew through the de novo pathway or recycled/modulated by the salvage pathway. This synthesis is crucial for cell growth, division, and maintenance.
Tips
A common mistake is confusing the de novo and salvage pathways or their functions; remember, de novo synthesizes from scratch, while salvage recycles components.
Sources
- Purine and Pyrimidine Metabolism - library.med.utah.edu
- Purines and pyrimidines - Knowledge @ AMBOSS - amboss.com
- Pyrimidine Nucleotide - an overview | ScienceDirect Topics - sciencedirect.com
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