Proline is referred to as the 'helix breaker' because...
Understand the Problem
The question is asking for the reason why proline is termed the 'helix breaker' in the context of protein structure. It requires an understanding of the properties of proline and its effects on helical structures in proteins.
Answer
Proline is called a 'helix breaker' due to its cyclic structure which introduces kinks in polypeptide chains.
Proline is referred to as the 'helix breaker' because its cyclic structure introduces kinks in the polypeptide chain, disrupting the regular backbone configuration and limiting the formation of alpha-helices. Its unique rigidity prevents the necessary hydrogen bonding for stable helical structures.
Answer for screen readers
Proline is referred to as the 'helix breaker' because its cyclic structure introduces kinks in the polypeptide chain, disrupting the regular backbone configuration and limiting the formation of alpha-helices. Its unique rigidity prevents the necessary hydrogen bonding for stable helical structures.
More Information
Proline's unique cyclic structure and side-chain constraints make it rigid, preventing it from fitting into the regular helical pattern of alpha-helices. This makes it integral in situations where flexibility or sharp turns in the protein backbone are necessary.
Tips
A common misconception might be confusing the reason it's a 'helix breaker' with simply lacking hydrogen atoms rather than its structural geometry and rigidity.
Sources
- Proline is referred to as the 'helix breaker' because... - brainly.com
- Solved Proline is called 'alpha-helix breaker' - chegg.com
- Which amino acid among the standard amino acids is called helix breaker? - homework.study.com
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