Match the following drug actions with their respective descriptions: Enzyme inhibitor | Binds to a site on the receptor different from the active site Antagonist | Acts as a pseudo... Match the following drug actions with their respective descriptions: Enzyme inhibitor | Binds to a site on the receptor different from the active site Antagonist | Acts as a pseudosubstrate for an enzyme Agonist | Inhibits the activity of an enzyme Orthosteric modulator | Binds to the active site on the receptor Allosteric modulator | Blocks the action of an endogenous messenger
Understand the Problem
The question is asking to match different drug actions with their corresponding descriptions. This involves identifying which description accurately reflects the nature of the specified drug action.
Answer
1. Enzyme inhibitor: Inhibits enzyme activity 2. Antagonist: Blocks endogenous messenger 3. Agonist: Binds to active site 4. Orthosteric modulator: Binds to active site 5. Allosteric modulator: Binds to different site
Enzyme inhibitor: Inhibits the activity of an enzyme; Antagonist: Blocks the action of an endogenous messenger; Agonist: Binds to the active site on the receptor; Orthosteric modulator: Binds to the active site on the receptor; Allosteric modulator: Binds to a site on the receptor different from the active site.
Answer for screen readers
Enzyme inhibitor: Inhibits the activity of an enzyme; Antagonist: Blocks the action of an endogenous messenger; Agonist: Binds to the active site on the receptor; Orthosteric modulator: Binds to the active site on the receptor; Allosteric modulator: Binds to a site on the receptor different from the active site.
More Information
An allosteric modulator changes the receptor's shape to influence its activity without competing directly with natural neurotransmitter binding sites. This mechanism often provides drugs with greater specificity and fewer side effects.
Tips
A common mistake is confusing allosteric modulators with orthosteric modulators. Remember that allosteric modulators bind to sites distinct from the active site.
Sources
- Drugs for Allosteric Sites on Receptors - PMC - PubMed Central - pmc.ncbi.nlm.nih.gov
- Pharmacological Glossary - Tocris Bioscience - tocris.com
- International Union of Pharmacology Committee on Receptor ... - guidetopharmacology.org
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