In the diagnosis of prePMF, which condition must be present to meet a major criterion?
Understand the Problem
The question is asking about the diagnostic criteria for pre-Polycythemia Vera Myelofibrosis (prePMF) and what major condition must be present to meet the diagnosis. This indicates a need for knowledge in the field of hematology and specifically myeloproliferative disorders.
Answer
Megakaryocytic proliferation and atypia in the bone marrow.
The condition that must be present to meet a major criterion in the diagnosis of prePMF is megakaryocytic proliferation and atypia in the bone marrow.
Answer for screen readers
The condition that must be present to meet a major criterion in the diagnosis of prePMF is megakaryocytic proliferation and atypia in the bone marrow.
More Information
The presence of megakaryocytic proliferation and atypia in the bone marrow is necessary as one of the major criteria for diagnosing pre-fibrotic primary myelofibrosis (prePMF). This reflects the abnormal increase and abnormal shape of certain precursor cells in the bone marrow.
Tips
A common mistake is confusing criteria for different stages of myelofibrosis or related conditions like essential thrombocythemia.
Sources
- Prefibrotic primary myelofibrosis - Wikipedia - en.wikipedia.org
- Myelofibrosis Diagnosis | MIMS Malaysia - mims.com
- SOHO State of the Art Updates and Next Questions - sciencedirect.com
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