How will LS's warfarin need to be adjusted due to elevated T3/T4 levels?
Understand the Problem
The question is asking how the patient's warfarin dosage should be adjusted due to their diagnosis of hyperthyroidism, specifically seeking clarification on the implications of elevated T3/T4 levels on warfarin metabolism.
Answer
Decrease the dose due to increased metabolism of clotting factors.
Decrease the warfarin dose as elevated T3/T4 causes increased metabolism of vitamin K dependent clotting factors.
Answer for screen readers
Decrease the warfarin dose as elevated T3/T4 causes increased metabolism of vitamin K dependent clotting factors.
More Information
In hyperthyroid states, increased thyroid hormones lead to faster metabolism of vitamin K dependent clotting factors, requiring a reduced warfarin dose to avoid excessive anticoagulation.
Tips
A common mistake is not considering the metabolic changes in the hyperthyroid state that affect clotting factors.
Sources
- Graves' Disease and Treatment Effects on Warfarin Anticoagulation - pmc.ncbi.nlm.nih.gov
- Effect of Thyroid Dysfunction on Response to Warfarin | Consultant360 - consultant360.com
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