How does the binding of a drug to a protein in the blood affect its rate of glomerular filtration?
Understand the Problem
The question is exploring how the interaction between a drug and a protein in the blood influences the rate at which the drug is filtered through the kidneys. It specifically looks at the implications of protein binding on the filtration process in the glomerulus.
Answer
Protein binding reduces drug excretion rate via glomerular filtration.
When a drug binds to proteins in the blood, it generally decreases the drug's rate of renal excretion through glomerular filtration, as only free (unbound) drugs can be filtered by the kidneys.
Answer for screen readers
When a drug binds to proteins in the blood, it generally decreases the drug's rate of renal excretion through glomerular filtration, as only free (unbound) drugs can be filtered by the kidneys.
More Information
Protein-bound drugs do not pass through the glomerulus as effectively as free drugs. Therefore, protein binding often delays the elimination of drugs from the body, affecting their efficacy and dosage requirements.
Tips
A common mistake is assuming that protein-bound drugs can be excreted at the same rate as free drugs. Remember that only unbound drugs can be filtered through the kidneys.
Sources
- An overview of Drug Protein Binding - ScienceDirect - sciencedirect.com
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