How do COX-1 and COX-2 differ in their roles in the body?
Understand the Problem
The question is asking to compare the roles of COX-1 and COX-2 enzymes in the body and identify their differences. It presents multiple-choice options that outline these differences.
Answer
COX-1 is protective, COX-2 mediates inflammation.
COX-1 is involved in protective processes such as maintaining the stomach lining and renal function, while COX-2 is primarily involved in mediating inflammation and pain.
Answer for screen readers
COX-1 is involved in protective processes such as maintaining the stomach lining and renal function, while COX-2 is primarily involved in mediating inflammation and pain.
More Information
COX-1 and COX-2 are enzymes that produce prostaglandins. COX-1 is generally involved in homeostatic functions like gastrointestinal protection and platelet function. On the other hand, COX-2 is induced by inflammatory stimuli and is involved in pain and inflammatory responses.
Tips
A common mistake is to assume that COX-2 is present only during inflammation, while it is actually inducible and can be found constitutively in some tissues.
Sources
- COX-1 and COX-2 in health and disease - PubMed - pubmed.ncbi.nlm.nih.gov
- Cyclooxygenase (COX) Enzymes, Inhibitors, and More - verywellhealth.com
- COX-2 Inhibitors: What They Are, Uses & Side Effects - my.clevelandclinic.org
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