Glucagon signaling sequentially activates the phosphorylase first, and then inhibits glycogen synthase. True or false?

Understand the Problem

The question is asking whether the statement about glucagon signaling is true or false, specifically regarding the sequence of activation and inhibition of phosphorylase and glycogen synthase.

More Information

Glucagon signaling activates phosphorylase, leading to glycogen breakdown, and sequentially inhibits glycogen synthase, preventing glycogen synthesis.

Tips

One common mistake is assuming that glucagon affects both processes equally and simultaneously, but it does act sequentially.

Sources

• Physiology, Glucagon - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
• 15.3: Glycogenolysis and its Regulation by Glucagon and ... - bio.libretexts.org