Functional cloning
Understand the Problem
The question appears to be asking about the concept of functional cloning, which typically relates to genetics and molecular biology. This may involve discussions about techniques used to isolate and replicate a specific gene or segment of DNA that is responsible for a particular function.
Answer
Functional cloning identifies genes based on protein sequence/function knowledge.
Functional cloning is a molecular cloning technique that identifies genes based on prior knowledge of the encoded protein's sequence or function.
Answer for screen readers
Functional cloning is a molecular cloning technique that identifies genes based on prior knowledge of the encoded protein's sequence or function.
More Information
Functional cloning is especially useful in identifying genes linked to specific diseases by exploiting known protein dysfunction. It helps in sequencing proteins and designing cDNA probes to find the corresponding genes.
Tips
A common mistake is confusing functional cloning with positional cloning; functional cloning relies on protein function knowledge whereas positional cloning identifies gene location through chromosomal features.
Sources
- Functional cloning - Wikipedia - en.wikipedia.org
- Functional Cloning - an overview | ScienceDirect Topics - sciencedirect.com
- Functional Cloning - an overview | ScienceDirect Topics - sciencedirect.com
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