Discuss the function of: a. Lipoprotein lipase b. Hormone sensitive lipase. Make it longer.
Understand the Problem
The question is asking for a detailed discussion on the functions of two enzymes: lipoprotein lipase and hormone-sensitive lipase. It requires an explanation of how each enzyme works, their physiological roles, and their importance in metabolism, particularly in the context of lipid utilization and regulation in the body.
Answer
Lipoprotein lipase hydrolyzes extracellular triglycerides in lipoproteins, while hormone-sensitive lipase hydrolyzes intracellular triglycerides in adipocytes.
Lipoprotein lipase (LPL) hydrolyzes extracellular triglycerides circulating in the bloodstream found in lipoproteins like chylomicrons and very low-density lipoproteins (VLDL), releasing free fatty acids for uptake by tissues. Hormone-sensitive lipase (HSL) is an intracellular enzyme that primarily acts in adipocytes to mobilize stored fats by hydrolyzing triglycerides into free fatty acids and glycerol, stimulated by hormonal signals during energy demand.
Answer for screen readers
Lipoprotein lipase (LPL) hydrolyzes extracellular triglycerides circulating in the bloodstream found in lipoproteins like chylomicrons and very low-density lipoproteins (VLDL), releasing free fatty acids for uptake by tissues. Hormone-sensitive lipase (HSL) is an intracellular enzyme that primarily acts in adipocytes to mobilize stored fats by hydrolyzing triglycerides into free fatty acids and glycerol, stimulated by hormonal signals during energy demand.
More Information
Lipoprotein lipase is crucial for energy delivery to tissues such as skeletal and cardiac muscle. Hormone-sensitive lipase responds to hormonal signals like epinephrine and decreases in response to insulin to regulate energy balance.
Tips
Avoid confusing lipoprotein lipase and hormone-sensitive lipase as both deal with triglycerides but in different tissue localizations and functional contexts.
Sources
- Hormone-Sensitive Lipase - an overview | ScienceDirect Topics - sciencedirect.com
- An Overview of Hormone-Sensitive Lipase (HSL) - PMC - pmc.ncbi.nlm.nih.gov
- Hormone-sensitive lipase - Journal of Lipid Research - jlr.org
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