Describe the tertiary ribbon structure of botox A.
Understand the Problem
The question is asking for a description of the tertiary ribbon structure of botox A, which involves understanding its molecular arrangement and interaction. The tertiary structure refers to the three-dimensional shape formed by the folding of a protein, which is crucial for its function.
Answer
BoNT/A tertiary ribbon structure has three lobes: light chain, amino-terminal of heavy chain, and carboxyl-terminal of heavy chain with central alpha-helices and a 50-residue loop.
The tertiary ribbon structure of Botox A (BoNT/A) consists of three primary lobes - the light chain (LC), the amino-terminal portion of the heavy chain (HN), and the carboxyl-terminal portion of the heavy chain (HC). The translocation domain contains a central pair of alpha-helices and a loop of approximately 50 residues.
Answer for screen readers
The tertiary ribbon structure of Botox A (BoNT/A) consists of three primary lobes - the light chain (LC), the amino-terminal portion of the heavy chain (HN), and the carboxyl-terminal portion of the heavy chain (HC). The translocation domain contains a central pair of alpha-helices and a loop of approximately 50 residues.
More Information
Botox A (BoNT/A) has a unique structure that allows it to interact specifically with nerve cells, making it effective in medical and cosmetic applications.
Sources
- Botulinum toxin - Wikipedia - en.wikipedia.org
- 3BTA: CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN - rcsb.org
- Botulinum toxin type A: Uses, Interactions, Mechanism of Action - go.drugbank.com
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