At what point will the urinary excretion of methysergide become maximal?
Understand the Problem
The question is asking about the conditions under which the urinary excretion of methysergide reaches its maximum. It focuses on the drug's ionization, which is influenced by pH and pKa. The options provided suggest different scenarios related to pH and drug concentration, requiring an understanding of pharmacokinetics.
Answer
1-2 hours after administration.
The urinary excretion of methysergide becomes maximal at around 1-2 hours after administration.
Answer for screen readers
The urinary excretion of methysergide becomes maximal at around 1-2 hours after administration.
More Information
Methysergide is rapidly absorbed with peak plasma levels occurring within about an hour, and maximal urinary excretion occurring shortly after.
Tips
A common mistake is confusing peak plasma concentration with urinary excretion timing. These are related but not the same.
Sources
- Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic ... - pmc.ncbi.nlm.nih.gov
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