A 42-year-old male presents to the dermatology clinic with a history of leprosy for which he has been on long-term multidrug therapy. He complains of gradually darkening skin and t... A 42-year-old male presents to the dermatology clinic with a history of leprosy for which he has been on long-term multidrug therapy. He complains of gradually darkening skin and thickening of the skin that has developed over the past few months. Physical examination reveals hyperpigmentation and ichthyosis-like scaling, predominantly on his extremities. Which of the following medications is most likely responsible for these side effects? A) Dapsone B) Clofazimine C) Steroids D) Rifampicin
Understand the Problem
The question presents a clinical scenario about a 42-year-old male patient with a history of leprosy who has developed skin thickening and ichthyosis-like scaling while on long-term drug therapy. It asks which medication is most likely responsible for these side effects, based on the patient's symptoms and treatment history.
Answer
Clofazimine
The final answer is Clofazimine.
Answer for screen readers
The final answer is Clofazimine.
More Information
Clofazimine is known to cause hyperpigmentation and ichthyosis-like alterations in patients undergoing long-term treatment for leprosy.
Tips
A common mistake is not associating hyperpigmentation specifically with Clofazimine and confusing it with the side effects of other leprosy medications.
Sources
- Leprosy | StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Leprosy - an overview | ScienceDirect Topics - sciencedirect.com
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