A 27-year-old man with HIV disease and hepatic insufficiency presents to his primary care physician complaining of rectal pain and bleeding with bowel movements. Physical examinati... A 27-year-old man with HIV disease and hepatic insufficiency presents to his primary care physician complaining of rectal pain and bleeding with bowel movements. Physical examination reveals several internal and external hemorrhoids. The patient would like to avoid surgical therapy for this condition. Which of the following routes of drug administration would be preferred in this patient? (A) Enteral (B) Intramuscular (C) Intravenous (D) Rectal (E) Transdermal
Understand the Problem
The question is asking for the preferred route of drug administration for a patient with HIV and hepatic insufficiency who is experiencing hemorrhoidal pain and bleeding, and wishes to avoid surgery. The context implies a consideration of the patient's condition and potential complications when determining the best route.
Answer
Transdermal
The final answer is Transdermal.
Answer for screen readers
The final answer is Transdermal.
More Information
In this patient with hepatic insufficiency, transdermal administration avoids first-pass metabolism in the liver, reducing potential hepatic strain while providing systemic drug delivery.
Tips
A common mistake is opting for oral or enteral routes, which would impact the liver more severely due to first-pass metabolism.
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