T1 L16: Causation & Study Design: HIV & AIDS (TGJ)

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Questions and Answers

Which study design attempts to control and monitor potential confounding variables and manipulate a variable of interest in order to establish cause and effect?

  • Analytic study (correct)
  • Case-control study
  • Cross-sectional study
  • Descriptive study

What is the purpose of a case-control study design?

  • To review study designs taught in 203
  • To control and monitor potential confounding variables
  • To establish cause and effect
  • To understand the relationship between variables (correct)

What is the main difference between a case-control study design and a cross-sectional study design?

  • The ability to establish cause and effect
  • The manipulation of a variable of interest (correct)
  • The purpose of the study design
  • The control and monitoring of potential confounding variables

What is the purpose of the Bradford-Hill criteria?

<p>To establish cause and effect (D)</p> Signup and view all the answers

What does a confounder variable influence in a study?

<p>The association between variables (A)</p> Signup and view all the answers

What is the purpose of a cross-sectional study design?

<p>To understand the relationship between variables (A)</p> Signup and view all the answers

What do correlation and association studies aim to understand?

<p>The relationship between variables (C)</p> Signup and view all the answers

Which study design involves random allocation into groups and is considered the gold standard for establishing causation?

<p>Randomised Controlled Trial (D)</p> Signup and view all the answers

Which study design is used to calculate incidences or new onsets of a disease?

<p>Cohort study (D)</p> Signup and view all the answers

Which study design involves selecting two groups of participants - one with the condition (cases) and one without (controls) - and matching variables not of interest at selection?

<p>Case-control study (D)</p> Signup and view all the answers

Which study design involves selecting participants based on exposure and putting them into exposed vs non-exposed groups?

<p>Cohort study (A)</p> Signup and view all the answers

Which study design involves surveying a population to measure health outcomes, exposure, and demographics at a specific time and place?

<p>Cross-sectional study (B)</p> Signup and view all the answers

Which study design is always carried out retrospectively and selects the sample based on outcome status?

<p>Case-control study (B)</p> Signup and view all the answers

Which study design is used to identify relevant exposures quickly and easily and collects data from surveys or patient records?

<p>Case-control study (D)</p> Signup and view all the answers

According to the Bradford-Hill criteria, which of the following is NOT one of the criteria for causation?

<p>Biological gradient (D)</p> Signup and view all the answers

Which of the following best describes the temporal relationship criterion for causation according to the Bradford-Hill criteria?

<p>The exposure must precede the disease (C)</p> Signup and view all the answers

In the context of the HIV/AIDS case-control study, what does the term 'specificity' refer to?

<p>The development of AIDS only in people with HIV (A)</p> Signup and view all the answers

Which of the following best describes the consistency criterion for causation according to the Bradford-Hill criteria?

<p>The association must be consistent across different studies (C)</p> Signup and view all the answers

What is the main purpose of a cohort study in the context of studying HIV/AIDS?

<p>To determine the strength of association between HIV and AIDS (A)</p> Signup and view all the answers

Which of the following best describes the plausibility criterion for causation according to the Bradford-Hill criteria?

<p>The association must be plausible (C)</p> Signup and view all the answers

In the context of the HIV/AIDS case-control study, what does the term 'analogy' refer to?

<p>The association analogues to known causal relationship (C)</p> Signup and view all the answers

Which of the following is a key factor in the progression to AIDS and mortality in individuals with HIV?

<p>Increased viral loads (C)</p> Signup and view all the answers

Which of the following best describes the strength of association between HIV viral load and AIDS incidence?

<p>Strong association (D)</p> Signup and view all the answers

Which type of study design is considered the best evidence for establishing a causal association between exposure and outcome?

<p>Randomized Controlled Trial (RCT) (B)</p> Signup and view all the answers

Which criterion for causation according to the Bradford-Hill criteria refers to the presence of a plausible pathophysiological mechanism linking HIV to AIDS?

<p>Plausibility (C)</p> Signup and view all the answers

Which of the following is NOT one of the four key types of study design mentioned in the text?

<p>Randomized Controlled Trial (RCT) (B)</p> Signup and view all the answers

Which study design involves selecting participants based on exposure and putting them into exposed vs non-exposed groups?

<p>Case-control study (C)</p> Signup and view all the answers

Which criterion for causation according to the Bradford-Hill criteria refers to the presence of similar animal viruses causing immunodeficiency, wasting disorders, neurodegeneration, and death?

<p>Analogy (D)</p> Signup and view all the answers

Which type of study design is always carried out retrospectively and selects the sample based on outcome status?

<p>Case-control study (A)</p> Signup and view all the answers

Which criterion for causation according to the Bradford-Hill criteria refers to the presence of experimental evidence supporting the association between reduced viral loads and reduced AIDS incidence?

<p>Experimental evidence (B)</p> Signup and view all the answers

Which of the following best describes the purpose of epidemiological research?

<p>To understand associations between exposures and outcomes (A)</p> Signup and view all the answers

What does the term 'causation' refer to in the context of epidemiological research?

<p>The relationship between exposures and outcomes (B)</p> Signup and view all the answers

Which of the following best describes the purpose of a case-control study design?

<p>To identify relevant exposures quickly and easily (D)</p> Signup and view all the answers

Which of the following best describes the difference between analytical and descriptive study designs?

<p>Analytical study designs aim to establish causation, while descriptive study designs focus on describing associations (C)</p> Signup and view all the answers

Which study design is considered the gold standard for establishing causation?

<p>Randomized controlled trial (B)</p> Signup and view all the answers

What is the purpose of the Bradford-Hill criteria?

<p>To establish causation in observational studies (D)</p> Signup and view all the answers

Which criterion for causation according to the Bradford-Hill criteria refers to the presence of a plausible pathophysiological mechanism linking exposure to outcome?

<p>Plausibility (A)</p> Signup and view all the answers

What is the main purpose of a case-control study design?

<p>To select participants based on exposure and put them into exposed vs non-exposed groups (A)</p> Signup and view all the answers

Which of the following study designs is NOT able to show temporal specificity?

<p>Cross-sectional study (D)</p> Signup and view all the answers

Which study design is commonly used to identify exposures quickly and easily, often collecting data from surveys or patient records?

<p>Cross-sectional study (A)</p> Signup and view all the answers

Which criterion for causation according to the Bradford-Hill criteria refers to the presence of a plausible pathophysiological mechanism linking HIV to AIDS?

<p>Plausibility (D)</p> Signup and view all the answers

Which study design involves selecting participants based on exposure and putting them into exposed vs non-exposed groups?

<p>Case-control study (B)</p> Signup and view all the answers

Which of the following is NOT one of the criteria for causation according to the Bradford-Hill criteria?

<p>Biological gradient (A)</p> Signup and view all the answers

What does the criterion of specificity in the Bradford-Hill criteria for causation mean?

<p>An association is associated with a single disease of interest (C)</p> Signup and view all the answers

Which criterion for causation according to the Bradford-Hill criteria refers to the presence of a plausible pathophysiological mechanism linking HIV to AIDS?

<p>Plausibility (B)</p> Signup and view all the answers

What is the purpose of a cross-sectional study design?

<p>To survey a population to measure health outcomes, exposure, and demographics at a specific time and place (B)</p> Signup and view all the answers

Which study design is best for measuring prevalence and looking for associations, but not good for measuring causation?

<p>Cross-sectional study (A)</p> Signup and view all the answers

What is the main difference between a case-control study design and a cross-sectional study design?

<p>The selection of participants (C)</p> Signup and view all the answers

Which criterion for causation according to the Bradford-Hill criteria refers to the presence of a plausible pathophysiological mechanism linking variables?

<p>Plausibility (A)</p> Signup and view all the answers

Which type of study design is always carried out retrospectively and selects the sample based on outcome status?

<p>Case-control study (D)</p> Signup and view all the answers

Which type of study design involves selecting participants based on exposure and putting them into exposed vs non-exposed groups?

<p>Case-control study (D)</p> Signup and view all the answers

Which of the following best describes the plausibility criterion for causation according to the Bradford-Hill criteria?

<p>There is a plausible pathophysiological mechanism linking the exposure to the outcome. (A)</p> Signup and view all the answers

Which of the following best describes the consistency criterion for causation according to the Bradford-Hill criteria?

<p>The association between the exposure and outcome is consistent across multiple studies. (C)</p> Signup and view all the answers

Which of the following is NOT one of the four key types of study design mentioned in the text?

<p>Experimental study (B)</p> Signup and view all the answers

Which of the following best describes the biological gradient criterion for causation according to the Bradford-Hill criteria?

<p>The greater viral load of HIV leading to a greater progression and mortality of AIDS. (A)</p> Signup and view all the answers

Which of the following study designs is considered the best evidence for establishing a causal association between HIV and AIDS?

<p>Randomized controlled trial (B)</p> Signup and view all the answers

What does the term 'plausibility' refer to in the context of the HIV/AIDS case-control study?

<p>The presence of a unique physiological mechanism of how HIV aids through the loss of lymphocytes compared to other similar animal viruses causing immunodeficiencies. (C)</p> Signup and view all the answers

Which of the following best describes the analogy criterion for causation according to the Bradford-Hill criteria?

<p>The association between HIV and AIDS across multiple study designs, locations, settings, and time. (C)</p> Signup and view all the answers

What is the main purpose of a cross-sectional study design in the context of studying HIV/AIDS?

<p>To identify relevant exposures quickly and easily and collect data from surveys or patient records. (C)</p> Signup and view all the answers

Which of the following is NOT one of the criteria for causation according to the Bradford-Hill criteria?

<p>Biological gradient (D)</p> Signup and view all the answers

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