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Questions and Answers
What is the primary role of neutrophils during the inflammation phase of wound healing?
What is the primary role of neutrophils during the inflammation phase of wound healing?
- Replenishment of lost tissue
- Formation of new blood vessels
- Elimination of dead tissue
- Prevention of infection (correct)
Which of the following processes occurs first in the wound healing cascade?
Which of the following processes occurs first in the wound healing cascade?
- Coagulation (correct)
- Epithelialization
- Debridement
- Remodelling
During which phase of wound healing do fibroblasts primarily contribute to tissue formation?
During which phase of wound healing do fibroblasts primarily contribute to tissue formation?
- Debridement
- Inflammation
- Resolution
- Proliferation and Migration (correct)
What is the main focus of the remodelling phase in wound healing?
What is the main focus of the remodelling phase in wound healing?
Which event is primarily associated with the process of angiogenesis during wound healing?
Which event is primarily associated with the process of angiogenesis during wound healing?
Flashcards
Wound Healing
Wound Healing
The process of wound healing involves a series of overlapping and coordinated events, which are orchestrated by a complex interaction between cells and the extracellular matrix.
Coagulation
Coagulation
The first stage of wound healing is characterized by the formation of a blood clot, which isolates the wound from the environment and prevents infection.
Inflammation
Inflammation
The inflammatory stage brings in immune cells (neutrophils and macrophages) to fight off invaders and clean up debris. This stage is crucial for preventing infection and setting the stage for repair.
Proliferation and Migration
Proliferation and Migration
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Remodeling
Remodeling
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Study Notes
Wound Healing Cascades
- Wound healing involves overlapping, stereotypical events with coordinated cell-cell and cell-matrix interactions.
- Bleeding (minutes - 1 hour): Isolation from the environment by a fibrin clot (scab) prevents further loss of blood.
- Inflammation (continuous): Neutrophils, followed by macrophages, prevent infection/septicemia.
- Debridement (day 1): Macrophages eliminate damaged tissue through phagocytosis.
- Proliferation/Migration (day 3): Lost tissue is replenished by fibroblasts, new capillaries, and parenchymal cells.
Wound Healing Steps
- Epithelialization: Parenchyma regeneration occurs.
- Angiogenesis: Granulation tissue receives nutrition.
- Fibroplasia: Fibroblast invasion and matrix production.
- Remodeling: ECM (extracellular matrix) generation and degeneration.
- Contraction: Wound edges close.
- Resolution: Restoration of appearance and function.
Wound Healing Maturation
- Maturation: Collagen type III is replaced by collagen type I with a perpendicular orientation.
Tissue Regeneration – Basic Steps
- Tissue damage: Initial tissue disruption.
- Bacteria, if present: The need for protection from bacteria is essential in preventing infection.
- Tissue repair: The repair process will involve the creation of new tissue to replicate lost cells, with new tissue formed.
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