Wound Healing Process Overview

The process of restoring damaged tissue to its original state or a functional equivalent.

A series of overlapping events involving cell-to-cell and cell-to-matrix interactions that occur in a coordinated manner to repair a damaged tissue.

The initial phase of wound healing where blood clots form to prevent further bleeding and isolate the wound from the environment.

The stage of wound healing where immune cells like neutrophils and macrophages arrive at the site to clear debris and fight infection.

The phase of wound healing where new cells and blood vessels are formed to replace lost tissue.

A blood clot that forms within a blood vessel, obstructing blood flow.

Alternating layers of pale (platelets and fibrin) and dark (red blood cells and fibrin) material found within a thrombus, indicating its formation in flowing blood.

Conditions that promote the formation of blood clots, often leading to blockage of blood vessels.

Hormonal changes associated with pregnancy can increase the risk of thrombus formation due to changes in blood composition and other factors.

Compression of the vena cava, a major vein in the body, can restrict blood flow and increase the likelihood of thrombus formation.

The process of blood clotting, triggered by injury or other factors, leading to the formation of a thrombus.

A type of cancer that originates in glandular tissue, often characterized by the production of mucin.

A substance produced by certain cells, often found in adenocarcinomas, possessing a sticky or gel-like consistency.

A blood clot that forms within a blood vessel, obstructing blood flow.

Alternating layers of light (platelets and fibrin) and dark (red blood cells and fibrin) material found within a thrombus, indicating its formation in flowing blood.

Conditions that promote the formation of blood clots, often leading to blockage of blood vessels.

Blood clots that lack the characteristic Lines of Zahn layers, often described as having a "chicken fat" appearance.

Clots formed before death, characterized by the presence of Lines of Zahn.

A process where a thrombus dissolves and disappears, mediated by the fibrinolytic cascade.

The process where a thrombus breaks off and travels through the bloodstream, potentially lodging in another vessel.

The process where a thrombus is transformed into fibrous tissue, often accompanied by recanalization and sometimes calcification.

A thrombus formed in an artery, primarily composed of platelet aggregation, often seen in conditions like atherosclerosis. These thrombi are usually pale in color due to the dominance of platelets and fibrin.

A thrombus formed in a vein, mainly composed of coagulated blood, often caused by slow blood flow or injury. These thrombi are usually dark red due to the presence of red blood cells and fibrin.

A thrombus that forms on a heart valve, typically associated with endocarditis. These thrombi are often composed of bacteria and fibrin, contributing to the infection.

A thrombus formed as a result of a spreading infection, often originating from a bacteria.

A condition characterized by unusual blood clotting in different parts of the body, often associated with cancer. This condition often progresses with clotting in various locations, like arms, legs, and knees.

A thrombus that forms within a tumor, often spreading the cancer cells through blood vessels.

A widespread clotting disorder characterized by the widespread formation of small blood clots (microthrombi) in the microcirculation. This can lead to organ damage and bleeding due to the consumption of clotting factors.

DIC is a condition where the balance between clot formation and clot breakdown is disrupted, leading to excessive clotting and bleeding simultaneously.

In DIC, the body tries to dissolve the numerous microcirculatory clots, leading to overactivation of the fibrinolytic system. This results in excessive plasmin generation, breaking down fibrin into FDPs and D-dimers.

The clotting cascade continuously forms new clots in DIC, overwhelming the fibrinolytic system that tries to dissolve them. This creates a vicious cycle of clot formation and dissolution.

In DIC, both clotting factors and platelets are consumed due to excessive clotting. This depletion of resources leads to consumptive coagulopathy, where the body struggles to form clots.

Excessive fibrinolysis in DIC weakens the ability to form stable clots needed to prevent bleeding. Furthermore, it inhibits clotting factors, aggravating uncontrolled bleeding.

High plasmin levels in DIC degrade fibrin clots, crucial for preventing bleeding, and inhibit clotting factors, resulting in hemorrhagic diathesis.

A blood clot that travels through the bloodstream and lodges in a narrower vessel, often causing blockage.

An embolus originating in the left heart or aorta, able to travel to any part of the body except the lungs.

An embolus originating from the right heart or peripheral veins, traveling to the lungs.

An unusual type of embolus that travels from the systemic veins to systemic arteries, often through a patent foramen ovale.

A type of embolus composed of a blood clot (thrombus) that breaks off and travels through the bloodstream.

Fibrin Degradation Products (FDPs) are byproducts of fibrinolysis, the breakdown of blood clots. Elevated FDPs indicate a lot of clot breakdown, which can happen in conditions like Disseminated Intravascular Coagulation (DIC).

D-dimers are fragments of fibrin, a protein involved in clot formation, that are released during fibrinolysis. High D-dimer levels are a sign of active blood clotting and breakdown.

Microangiopathic hemolytic anemia (MAHA) is a condition where red blood cells are damaged as they try to squeeze through narrowed blood vessels. This happens in DIC because small blood clots in the vessels (microthrombi) make the passage tight.

An embolus is a piece of solid, liquid, or gaseous material that travels through the bloodstream and can get lodged in a blood vessel, blocking blood flow.

Pylethrombosis is a blood clot that forms in the portal vein, which carries blood from the digestive system to the liver.

Deep vein thrombosis (DVT) is a blood clot that forms in a deep vein, usually in the legs. If the clot breaks loose, it can travel to the lungs and cause a pulmonary embolism.