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Wound Healing: Granulation Tissue

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Questions and Answers

What are the two primary components of granulation tissue?

Proliferation of new small blood vessels and proliferation of fibroblasts (correct)

Deposition of extracellular matrix and wound contraction

Proliferation of new small blood vessels and migration of fibroblasts

Migration and proliferation of fibroblasts and wound contraction

What is the primary function of myofibroblasts in wound healing?

Proliferation of new small blood vessels

Deposition of extracellular matrix

Wound contraction (correct)

Migration of fibroblasts into the site of injury

What is the primary component of extracellular matrix deposited during granulation tissue formation?

Elastin

Collagen type I

Collagen (correct)

Collagen type II

When does the formation of myofibroblasts begin during wound healing?

At day 6 (D) Signup and view all the answers

What is the term for the process of transformation of fibroblasts to muscle-like fibers during wound healing?

Myofibroblast transformation (C) Signup and view all the answers

What is the characteristic of healing by primary intention?

Minimum amount of time with minimal scar formation (B) Signup and view all the answers

What is the primary outcome of repair by scar formation?

Replacement by connective tissue (B) Signup and view all the answers

What occurs as early as 24 hours after injury in granulation tissue formation?

Fibroblasts and vascular endothelial cells begin proliferating (A) Signup and view all the answers

What is the characteristic appearance of young granulation tissue on the surface of the wound?

Pink, soft, and granular (B) Signup and view all the answers

What is the result of the remodeling phase of wound healing?

Maturation of collagen (B) Signup and view all the answers

What type of cells are most likely to undergo regeneration in tissue repair?

Labile cells (A) Signup and view all the answers

What is the term for the replacement of injured tissue with connective tissue in tissue repair?

Scar formation (C) Signup and view all the answers

What is a characteristic of secondary union healing?

Intense inflammatory reaction (C) Signup and view all the answers

What is a factor that can affect collagen synthesis and wound healing?

Protein deficiency (B) Signup and view all the answers

What is formed during the granulation tissue phase of wound healing?

Macrophages (C) Signup and view all the answers

What is a result of wound contraction during secondary union healing?

5 to 10% reduction in wound size (A) Signup and view all the answers

What is deposited during the ECM deposition phase of wound healing?

Collagen (A) Signup and view all the answers

What is the final outcome of the wound healing process?

Scar tissue (C) Signup and view all the answers