Lecture 12
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Questions and Answers

What is the primary objective of tissue repair?

  • To reduce chronic inflammation in organs
  • To restore tissue architecture and function after an injury (correct)
  • To regenerate damaged tissues completely
  • To promote scar formation in damaged tissues

    • What occurs when damaged tissues are incapable of complete restitution and regeneration?

  • Chronic inflammation in organs
  • Regeneration of residual undamaged cells
  • Scar formation through deposition of collagen (correct)
  • Complete recovery of tissue function

    • What is the term for the deposition of collagen in organs after chronic inflammation or infarction?

  • Fibrosis (correct)
  • Organization
  • Regeneration
  • Wound healing

    • What is the term for the process of laying down of connective tissue in a tissue space occupied by an inflammatory exudate?

    <p>Organization</p> Signup and view all the answers

    What is the primary characteristic of labile tissues?

    <p>Cells are continuously being lost and replaced by maturation from stem cells</p> Signup and view all the answers

    Which of the following tissues have a limited capacity to regenerate after injury?

    <p>Stable tissues except liver</p> Signup and view all the answers

    How are tissues categorized based on their intrinsic proliferative capacity?

    <p>Into three groups: labile, stable, and permanent tissues</p> Signup and view all the answers

    What is the term for the healing of wounds with minimal tissue damage and complete restitution?

    <p>Healing by first intention</p> Signup and view all the answers

    What is the characteristic of embryonic stem cells?

    <p>Can generate multiple cell lineages</p> Signup and view all the answers

    What is the function of stem cells in labile tissues?

    <p>To differentiate into mature cells and replace lost cells</p> Signup and view all the answers

    What is the main function of growth factors in tissue proliferation?

    <p>To stimulate the function of growth control genes</p> Signup and view all the answers

    In which stage of the cell cycle are cells in stable tissues?

    <p>G0 stage</p> Signup and view all the answers

    What is the role of autocrine signaling in growth factors?

    <p>Signaling directly in the same cell</p> Signup and view all the answers

    What happens to damaged permanent tissue?

    <p>It is repaired by scar formation</p> Signup and view all the answers

    Where are stem cells typically located in skin and GIT?

    <p>Near the basal layer of the epithelium</p> Signup and view all the answers

    Which of the following is NOT a growth promoter?

    <p>Tumor necrosis factor (TNF)</p> Signup and view all the answers

    What is the role of the extracellular matrix (ECM) in cell behavior?

    <p>To regulate cell movement and differentiation</p> Signup and view all the answers

    What is the characteristic of asymmetric replication?

    <p>Some cells enter a differentiation pathway, while others remain undifferentiated</p> Signup and view all the answers

    What is the characteristic appearance of granulation tissue?

    <p>Pink, soft, granular</p> Signup and view all the answers

    What is the primary reason for edema in granulation tissue?

    <p>Incompletely formed inter-endothelial junctions</p> Signup and view all the answers

    What is the function of VEGF in granulation tissue?

    <p>To increase vessel permeability</p> Signup and view all the answers

    In which type of tissues does cell renewal occur continuously?

    <p>Labile tissues</p> Signup and view all the answers

    What is the characteristic of the extracellular matrix in granulation tissue?

    <p>Loose and fibrous</p> Signup and view all the answers

    What percentage of the liver can be removed in living donor or for tumor removal?

    <p>40% to 60%</p> Signup and view all the answers

    What is the outcome of the accumulation of connective tissue matrix in granulation tissue?

    <p>Formation of scar tissue</p> Signup and view all the answers

    What drives the proliferation of more differentiated progenitors in the bone marrow?

    <p>Growth factors</p> Signup and view all the answers

    What is required for tissue regeneration and repair?

    <p>Intact ECM</p> Signup and view all the answers

    Which organs have some regenerative capacity?

    <p>Pancreas, adrenal, thyroid, and lung</p> Signup and view all the answers

    When can repair occur through regeneration alone?

    <p>When there is minimal damage to tissues</p> Signup and view all the answers

    What is the characteristic gross appearance of granulation tissue?

    <p>Pink, soft, granular</p> Signup and view all the answers

    What is the primary reason for the edematous nature of granulation tissue?

    <p>Incompletely formed inter-endothelial junctions</p> Signup and view all the answers

    What is the result of the accumulation of connective tissue matrix in granulation tissue?

    <p>Formation of a scar</p> Signup and view all the answers

    What is the function of VEGF in granulation tissue?

    <p>Increases vessel permeability</p> Signup and view all the answers

    What is the characteristic microscopic appearance of granulation tissue?

    <p>Proliferating fibroblasts and new blood vessels</p> Signup and view all the answers

    How long does it take for granulation tissue to become apparent?

    <p>3 to 5 days</p> Signup and view all the answers

    What is the composition of granulation tissue?

    <p>Proliferating fibroblasts, new thin-walled capillaries, and loose ECM</p> Signup and view all the answers

    What is the ultimate outcome of the remodeling process in granulation tissue?

    <p>Formation of a permanent scar</p> Signup and view all the answers

    What is the significance of angiogenesis in granulation tissue?

    <p>Formation of new blood vessels</p> Signup and view all the answers

    What is the characteristic of the extracellular matrix in granulation tissue?

    <p>Loose and collagen-poor</p> Signup and view all the answers

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