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Questions and Answers
What are germ cells primarily responsible for?
What happens to the volume of a frog egg during cleavage?
Where do germ cells migrate to for differentiation?
How do most frog species fertilize their eggs?
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What is one effect of environmental factors on frog life cycles?
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What type of cells are formed from somatic cells?
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What facilitates the anchoring of frog eggs in certain species?
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What is the primary function of gametogenesis?
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What initiates the process of gametogenesis and fertilization in frogs?
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What is the primary function of fertilization in frogs?
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What role does the ectoderm play during frog development?
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What marks the future dorsal side of the embryo in frogs during gastrulation?
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Which germ layer is responsible for developing into connective tissues and muscles?
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What triggers the movement of cytoplasm inside the fertilized egg?
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During organogenesis, what is the function of the notochord?
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What does the endoderm develop into in frogs?
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What are the three germ layers identified by Christian Pander in the chick embryo?
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What is the primary role of the ectoderm in embryonic development?
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Which cell movement is NOT one of the five basic movements of gastrulation described by Pander?
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What does the endoderm mainly contribute to in the developing embryo?
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Which principle is essential for the proper development of germ layers according to Pander's findings?
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What significant contribution did Karl Ernst von Baer make to the understanding of vertebrate embryonic development?
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What is the function of the mesoderm during embryonic development?
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Which of the following is NOT produced by the ectoderm?
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What role do fate maps play in embryology?
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What does preformationism suggest about the development of organisms?
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Which of the following correctly describes cell migration during development?
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What concept did Johann Friedrich Blumenbach introduce to support preformationism?
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Which statement about cell growth is true?
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Who proposed a reconciliation between epigenesis and preformationism?
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How does apoptosis contribute to development?
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What is a significant advancement in fate map technology?
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What did E.B. Wilson note about cell division during cleavage in 1923?
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What aspect of embryonic development was supported by the lack of cell theory at the time?
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Which of the following describes a characteristic of germ cell development?
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What observation did Malpighi make regarding the unincubated chick egg that supported preformationism?
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What influence do changes in cell membrane composition have?
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Which cells undergo significant changes in size during development?
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In preformationism, what does the term 'prefigured state' refer to?
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What is a blastomere?
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Study Notes
Importance of Developmental Biology
- Developmental biology examines crucial issues that impact other fields like molecular biology, physiology, cell biology, genetics, and more.
- It explores how a single cell develops into a complex organism.
Gametogenesis
- A group of cells designated for reproductive function are known as germ cells.
- These cells migrate to the gonads where they differentiate during gametogenesis, the process of forming gametes (sperm and egg).
Frog Fertilization
- Most frog species fertilize externally.
- The male frog holds the female's back and fertilizes the eggs as she releases them.
- The eggs are often anchored to vegetation or float freely in a pond.
Cleavage and Gastrulation
- Cleavage: The zygote divides into thousands of cells, maintaining the same volume.
- Gastrulation: Initiated at the point opposite sperm entry. Â Â - Forms a dimple called a blastopore, marking the future dorsal side of the embryo. Â Â - Cells migrating through the blastopore become mesoderm and endoderm. Â Â - Cells remaining on the outside develop into ectoderm, eventually enclosing the embryo.
Germ Layers and Their Roles
- Ectoderm: Develops into the epidermis, brain, and nerves.
- Endoderm: Develops into the gut lining and respiratory systems.
- Mesoderm: Develops into connective tissue, muscle, blood, heart, skeleton, gonads, and kidneys
Organogenesis
- The dorsal mesoderm cells condense to form a notochord, a rod of cells that releases chemical signals influencing ectodermal cell fate.
- This process begins when the notochord releases chemical signals that influence the fate of the ectodermal cells above them.
Preformationism
- Suggested by Immanuel Kant and Johann Friedrich Blumenbach.
- This theory claimed that adult organs were in miniature within the sperm or egg.
- Supported by Malpighi's observations of structural complexity in unincubated chick eggs.
Support for Preformationism
- Embryonic development was considered a growth of existing structures, not the formation of new ones.
- A prefigured generation was believed to exist in germ cells of the current generation.
- The lack of cell theory at the time contributed to the persistence of this view.
Epigenesis
- Proposed by Blumenbach, who introduced the concept of Bildungstrieb (developmental force).
- It proposed that organisms are "constructed" rather than "unrolled."
- Blumenbach argued this force was observable through phenomena like the regeneration of hydra after amputation.
- Modern biology aligns with the idea that epigenetic development is directed by preformed instructions, present in the fertilized egg.
Patterns of Cleavage
- Blastomeres: The cells in the cleavage stage.
Discoveries of Christian Pander
- Studied the chick embryo and identified three germ layers: ectoderm, endoderm, and mesoderm.
- Demonstrated that the germ layers require induction to develop properly.
The Four Principles of Karl Ernst von Baer
- Expanded upon Pander's work, discovering that all vertebrate embryos follow a common developmental pattern.
- Introduced the concept of "fate mapping," a tool for identifying the adult structures that originate from specific embryonic regions.
Importance of Fate Maps
- They provide critical insights into the developmental lineages of embryonic cells.
- Advanced technology allows for more precise and detailed fate mapping.
Cell Migration
- Critical for proper development, as cells must move to their appropriate locations.
- Examples: Â Â - Germ cells migrating to the developing gonad. Â Â - Primordial heart cells meeting in the middle of the vertebrate neck and migrating to the left part of the chest.
Cell Growth
- Cells change in size during development, particularly evident in germ cells: Â Â - Sperm cells eliminate most of their cytoplasm and become smaller. Â Â - Egg cells conserve and add cytoplasm, becoming larger. Â Â - Asymmetric division can create one larger cell and one smaller cell with distinct fates.
Cell Death (Apoptosis)
- Cell death is a crucial aspect of development, as it removes unnecessary or unwanted cells.
- Examples: Â Â - Cells forming webbing between toes and fingers die before birth. Â Â - Cells in our tails also die. Â Â - Apoptosis contributes to the formation of orifices in the mouth, anus, and reproductive glands.
Changes in Cell Membrane Composition or Secreted Products
- Influence neighboring cells during development.
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