Weismann's Theory of Determinative Factors
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Weismann's Theory of Determinative Factors

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Questions and Answers

Weismann’s theory of determinative ______ are distributed unequally.

factors

The fate of each cell is predetermined by the ______ it receives.

factors

Cytoplasmic components are floating during ______.

cleavage

Weismann became a ______ as he developed his theories in the 1880s.

<p>Darwinist</p> Signup and view all the answers

Weismann is famous for the elucidation of the germ ______ theory.

<p>plasm</p> Signup and view all the answers

Factors in the nucleus are distributed ______ to cleavage partitions.

<p>asymmetrically</p> Signup and view all the answers

Weismann assumed that different ______ are directed to future development of daughter cells.

<p>ingredients</p> Signup and view all the answers

Cleavage partitions different ______ to daughter cells.

<p>ingredients</p> Signup and view all the answers

If you tie a loop of baby hair and tighten slowly to clearage each separate ______, both develop normally.

<p>blastomeres</p> Signup and view all the answers

Driesch concluded that sea urchin cleavage is ______.

<p>regulative</p> Signup and view all the answers

The phenomenon where half regular size – entelechy – is considered from a ______ perspective.

<p>vitalist</p> Signup and view all the answers

TH Morgan repeated Driesch’s sea urchin experiment – but this time on ______.

<p>frog</p> Signup and view all the answers

Both blastomeres developed into complete ______.

<p>embryos</p> Signup and view all the answers

Mosaic vs ______ development refers to different strategies of cell fate determination.

<p>regulative</p> Signup and view all the answers

______ development establishes cell fate later, via cell-cell interactions.

<p>Regulative</p> Signup and view all the answers

Mosaic or determinative development establishes cell fate at each ______ division.

<p>cell</p> Signup and view all the answers

The transition from maternal control of development to ______ control is most evident in animals with large eggs.

<p>zygotic</p> Signup and view all the answers

During the mid-blastula transition, many maternal mRNAs are actively ______.

<p>destroyed</p> Signup and view all the answers

The introduction of gap phases, G1 and G2, occurs during the slowing of the ______ cycle.

<p>cell</p> Signup and view all the answers

The process of counting cleavage divisions may control the timing of the ______.

<p>mid-blastula transition</p> Signup and view all the answers

Asynchronous divisions occur during the transition from early to late ______.

<p>blastula</p> Signup and view all the answers

Roux’s evidence for ______ development indicates a specific mechanism.

<p>mosaic</p> Signup and view all the answers

Frog cleavage divisions are described as strictly ______.

<p>mosaic</p> Signup and view all the answers

The undamaged cell survives while the ______ cell is destroyed.

<p>damaged</p> Signup and view all the answers

Roux's conclusion suggests no cells will form resembling a normal ______.

<p>embryo</p> Signup and view all the answers

In a mosaic development, the fate of the cells is ______ determined.

<p>pre</p> Signup and view all the answers

The cell can divide normally as long as it is ______.

<p>undamaged</p> Signup and view all the answers

If damaged, the cell may result in ______ formed structures.

<p>abnormal</p> Signup and view all the answers

Roux's evidence refutes the idea that frog cleavage leads to ______ characteristics.

<p>normal</p> Signup and view all the answers

By cycle 11 overall cyclin levels drop enough to get slowing of the cell cycle leading to a longer gap between cell divisions allowing some genes to be ______.

<p>transcribed</p> Signup and view all the answers

Transcription of genes that promote destruction of ______ leads to even longer gaps in cell division.

<p>Cdc25</p> Signup and view all the answers

Compaction in mammals results in the formation of a solid ball of cells known as a ______.

<p>morula</p> Signup and view all the answers

High level expression of E-cadherin, a cell-cell adhesion molecule, is crucial for cells to associate tightly with each ______.

<p>other</p> Signup and view all the answers

During compaction, cells on the inside of the morula will contribute to the ______.

<p>embryo</p> Signup and view all the answers

Compaction begins with the formation of a ______ layer that helps in the organization of the cells.

<p>trophectoderm</p> Signup and view all the answers

The completion of cleavage divisions leads to the blastula stage, also known as ______ or blastocyst depending on the organism.

<p>blastoderm</p> Signup and view all the answers

In most cases, the result of these divisions is an asymmetric embryo, with cells at different locations giving rise to different ______.

<p>cell types</p> Signup and view all the answers

The mouse blastocyst sits on top of yolk in a structure surrounded by a ______ layer.

<p>synctial</p> Signup and view all the answers

Cells undergo ______ to prepare for the next stage of development, gastrulation.

<p>cleavage</p> Signup and view all the answers

Study Notes

Weismann’s Theory of Determinative Development

  • Determinative factors are distributed unequally during cleavage, influencing each cell's fate.
  • Cell fates are predetermined based on cytoplasmic components received during cleavage.
  • Weismann introduced the germ plasm theory, focusing on the asymmetrical distribution of factors to daughter cells.

Mosaic Development

  • Mosaic development indicates that specific cell fates are established at the time of cell division.
  • Evidence from Roux showed that damaging one cell of a two-cell embryo resulted in no normal development of the damaged cell, confirming mosaic nature.
  • Frog cleavage demonstrates mosaic characteristics, but experiments show that normal development occurs even with disrupted conditions.

Driesch’s Evidence for Regulative Development

  • Driesch showed that sea urchin embryos could develop normally even when half was separated, suggesting that development could adapt.
  • The concept of entelechy suggests a vital force is at play, influencing organism development.
  • Variances in development between species may be due to different strategies for cell fate determination or experimental method discrepancies.

Experimental Findings by T.H. Morgan

  • Morgan’s experiments demonstrated that both blastomeres from frog eggs can develop into complete embryos when separated.
  • Indicates that sea urchins and frogs may adaptively regulate their development despite initial differences noted by Driesch.

Mosaic vs. Regulative Development

  • Regulative development relies on cell-cell interactions establishing cell fates later, dominating in late cleavage divisions.
  • Most organisms employ a mixed strategy that includes both mosaic and regulative development, with C. elegans exemplifying mostly mosaic development.

Mid-Blastula Transition (MBT)

  • Shift from maternal to zygotic control of development occurs during the MBT, significant in species with large eggs.
  • Early cleavage lacks transcription and occurs rapidly with no gap phases.
  • MBT introduces transcription, asynchronous cell divisions, and degradation of maternal mRNAs, allowing new genes to be expressed.

Mechanism of MBT

  • Timing of MBT may depend on several factors, including cleavage division counts and material depletion.
  • A drop in cyclin levels leads to prolonged cell cycle gaps, permitting gene transcription necessary for development and maternal mRNA degradation.

Compaction in Mammals

  • Compaction leads to a solid ball of cells (morula) transitioning to the blastocyst stage.
  • High expression of E-cadherin enhances cell adhesion, promoting tight cell associations and distinction of inner and outer cell types.
  • Inner cells contribute to the embryo, while outer cells form extra-embryonic structures and the placenta.

Blastula Stage

  • Known as blastoderm or blastocyst, depending on the organism, it represents the completion of cleavage divisions before gastrulation.
  • Typically results in an asymmetric embryo, where cells in varying positions develop into different cell types.

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This quiz delves into Weismann's theory of determinative factors and their unequal distribution in future generations. Explore the concepts of cleavage and hereditary determinants through a series of questions designed to test your understanding of this foundational biological theory.

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