Water Soluble Vitamins: Thiamin (Vitamin B1)

What is the other name for Thiamin?

What is the active form of thiamin?

Where does absorption of thiamin primarily occur?

What is the role of thiaminases in raw fish?

How is destruction of thiaminase in raw fish prevented?

Where is most free thiamin taken up following absorption?

What is the chief function of thiamin pyrophosphate (TPP)?

What is the deficiency disease associated with thiamin?

What are the symptoms of thiamin deficiency?

What is the neuropsychological complication associated with thiamin deficiency and alcoholism?

What are the symptoms of Wernicke-Korsakoff syndrome?

What are the other names for Riboflavin?

What are the chief functions of riboflavin?

What percentage of FAD is covalently bound to either histidine or cysteine in the intestinal lumen?

Which sources of B2 are better absorbed: animal or plant sources?

What happens to riboflavin upon absorption into intestinal cells?

Thiamin (Vitamin B1)

Also known as Vitamin B1.
Active form is Thiamin pyrophosphate (TPP).
Primarily absorbed in the small intestine.
Thiaminases, present in raw fish, degrade thiamin, leading to deficiency.
Cooking or processing fish effectively destroys thiaminases.

Thiamin Absorption and Function

After absorption, most free thiamin is taken up by the liver.
Chief function of TPP is as a coenzyme in carbohydrate metabolism, aiding in energy production.

Thiamin Deficiency

Deficiency disease associated with thiamin is Beriberi.
Symptoms include fatigue, weakness, nerve damage, and cardiovascular problems.
Wernicke-Korsakoff syndrome is the neuropsychological complication linked to thiamin deficiency, particularly in cases of alcoholism.
Symptoms of Wernicke-Korsakoff syndrome include confusion, memory loss, impaired coordination, and ocular disturbances.

Riboflavin (Vitamin B2)

Other names include Vitamin B2 and Lactoflavin.
Chief functions include energy production through the metabolism of fats, drugs, and steroids, and acting as a precursor for FAD and FMN.
Approximately 80% of FAD in the intestinal lumen is covalently bound to histidine or cysteine.
Riboflavin from animal sources is better absorbed than from plant sources.

Riboflavin Absorption

Upon absorption into intestinal cells, riboflavin is converted into its coenzyme forms (FAD and FMN) for use in various biochemical reactions.

Learn about the functions and stabilities of water soluble vitamins, with a specific focus on thiamin (Vitamin B1). Explore its discovery, structure, and active form, as well as its role as a coenzyme.