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Questions and Answers
What is the other name for Thiamin?
Vitamin B1
What is the active form of thiamin?
thiamin pyro-P (TDP/TPP)
Where does absorption of thiamin primarily occur?
jejunum
What is the role of thiaminases in raw fish?
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How is destruction of thiaminase in raw fish prevented?
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Where is most free thiamin taken up following absorption?
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What is the chief function of thiamin pyrophosphate (TPP)?
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What is the deficiency disease associated with thiamin?
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What are the symptoms of thiamin deficiency?
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What is the neuropsychological complication associated with thiamin deficiency and alcoholism?
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What are the symptoms of Wernicke-Korsakoff syndrome?
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What are the other names for Riboflavin?
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What are the chief functions of riboflavin?
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What percentage of FAD is covalently bound to either histidine or cysteine in the intestinal lumen?
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Which sources of B2 are better absorbed: animal or plant sources?
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What happens to riboflavin upon absorption into intestinal cells?
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Study Notes
Thiamin (Vitamin B1)
- Also known as Vitamin B1.
- Active form is Thiamin pyrophosphate (TPP).
- Primarily absorbed in the small intestine.
- Thiaminases, present in raw fish, degrade thiamin, leading to deficiency.
- Cooking or processing fish effectively destroys thiaminases.
Thiamin Absorption and Function
- After absorption, most free thiamin is taken up by the liver.
- Chief function of TPP is as a coenzyme in carbohydrate metabolism, aiding in energy production.
Thiamin Deficiency
- Deficiency disease associated with thiamin is Beriberi.
- Symptoms include fatigue, weakness, nerve damage, and cardiovascular problems.
- Wernicke-Korsakoff syndrome is the neuropsychological complication linked to thiamin deficiency, particularly in cases of alcoholism.
- Symptoms of Wernicke-Korsakoff syndrome include confusion, memory loss, impaired coordination, and ocular disturbances.
Riboflavin (Vitamin B2)
- Other names include Vitamin B2 and Lactoflavin.
- Chief functions include energy production through the metabolism of fats, drugs, and steroids, and acting as a precursor for FAD and FMN.
- Approximately 80% of FAD in the intestinal lumen is covalently bound to histidine or cysteine.
- Riboflavin from animal sources is better absorbed than from plant sources.
Riboflavin Absorption
- Upon absorption into intestinal cells, riboflavin is converted into its coenzyme forms (FAD and FMN) for use in various biochemical reactions.
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Description
Learn about the functions and stabilities of water soluble vitamins, with a specific focus on thiamin (Vitamin B1). Explore its discovery, structure, and active form, as well as its role as a coenzyme.
