Water-Soluble Vitamins
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Questions and Answers

What is the primary function of coenzymes in the body?

To interact with enzymes and regulate chemical reactions.

What is the result of combining a B vitamin with a nitrogen-containing, nonprotein compound in the body?

The synthesis of a coenzyme.

What is the fate of coenzymes in food or supplements when consumed?

They undergo digestion to release their B vitamin components.

Which B vitamins function as part of coenzymes involved in energy metabolism?

<p>Thiamin, riboflavin, niacin, vitamin B-6, and pantothenic acid.</p> Signup and view all the answers

What is the purpose of cells removing free vitamins from the bloodstream?

<p>To rebuild coenzymes.</p> Signup and view all the answers

Why is buying coenzyme supplements a waste of money?

<p>Because coenzymes in food or supplements are not absorbed intact and are broken down to release their B vitamin components.</p> Signup and view all the answers

What is the role of coenzymes in synthesizing glucose, amino acids, and certain lipids?

<p>Coenzymes containing B vitamins are necessary for their synthesis.</p> Signup and view all the answers

What are the main functions of water-soluble vitamins in the body?

<p>To function as components of coenzymes involved in various chemical reactions.</p> Signup and view all the answers

What is the major function of thiamin in the body?

<p>Part of coenzyme needed for carbohydrate metabolism and the metabolism of certain amino acids; may help neurotransmitter production</p> Signup and view all the answers

What are the major dietary sources of riboflavin?

<p>Milk, yogurt, and other milk products; enriched breads and cereals; liver</p> Signup and view all the answers

What is the major function of niacin in the body?

<p>Part of coenzymes needed for energy metabolism</p> Signup and view all the answers

What is the recommended daily intake of pantothenic acid for adults?

<p>5 mg</p> Signup and view all the answers

What is the major function of biotin in the body?

<p>Needed for synthesizing glucose and fatty acids</p> Signup and view all the answers

What is the major function of vitamin B-6 in the body?

<p>Part of coenzyme needed for amino acid metabolism, involved in neurotransmitter and hemoglobin synthesis</p> Signup and view all the answers

What is the major function of folate in the body?

<p>Part of coenzyme needed for DNA synthesis and conversion of cysteine to methionine, preventing homocysteine accumulation</p> Signup and view all the answers

What is the major function of vitamin B-12 in the body?

<p>Part of coenzymes needed for various cellular processes, including folate metabolism; maintenance of myelin sheaths</p> Signup and view all the answers

What is the major function of vitamin C in the body?

<p>Needed for connective tissue synthesis and maintenance; antioxidant; synthesis of neurotransmitters and certain hormones; immune system functioning</p> Signup and view all the answers

What is the major function of choline in the body?

<p>Neurotransmitter and phospholipid synthesis; methionine metabolism</p> Signup and view all the answers

What is the primary function of thiamin in the body?

<p>To make a coenzyme that participates in chemical reactions involved in the release of energy from carbohydrates.</p> Signup and view all the answers

What is the recommended daily intake of thiamin for adult men and women?

<p>1.2 mg/day for men and 1.1 mg/day for women</p> Signup and view all the answers

What is the name of the disease caused by a severe lack of thiamin?

<p>Beriberi</p> Signup and view all the answers

What is the degenerative brain disorder associated with thiamin deficiency in the United States?

<p>Wernicke-Korsakoff syndrome</p> Signup and view all the answers

What is the role of riboflavin in metabolism?

<p>Riboflavin is a component of two coenzymes that play key roles in the metabolism of carbohydrates, lipids, and amino acids.</p> Signup and view all the answers

Why should riboflavin-rich foods not be packaged or stored in clear glass containers?

<p>Because exposure to light causes riboflavin to break down rapidly.</p> Signup and view all the answers

What is the recommended daily intake of riboflavin for adult men and women?

<p>1.3 mg/day for men and 1.1 mg/day for women</p> Signup and view all the answers

What is the effect of cooking food in alkaline solutions on thiamin?

<p>It can destroy thiamin.</p> Signup and view all the answers

What are some good sources of thiamin?

<p>Whole-grain and enriched breads and cereals, pork, nuts, legumes, and orange juice.</p> Signup and view all the answers

What is the term for a chemical produced by a nerve cell that enables the cell to communicate with other nerve cells?

<p>Neurotransmitter</p> Signup and view all the answers

What side effects may occur in patients taking very high doses of niacin?,

<p>gastrointestinal ulcers, loss of vision, and liver damage</p> Signup and view all the answers

What is the role of vitamin B-6 in the synthesis of neurotransmitters?

<p>Vitamin B-6 is involved in the synthesis of neurotransmitters, which are chemicals that nerves produce to transmit messages.</p> Signup and view all the answers

Why were babies in the 1950s experiencing irritability and seizures?

<p>The vitamin B-6 in their infant formula was destroyed during manufacturing, leading to a lack of neurotransmitters in their brains.</p> Signup and view all the answers

What happens to vitamin B-6 during the refining process of grains?

<p>Vitamin B-6 is lost during the refining process and is not added back to the grain products during enrichment.</p> Signup and view all the answers

What is the range of the adult RDA for vitamin B-6?

<p>1.3 to 1.7 mg/day</p> Signup and view all the answers

What are the signs and symptoms of vitamin B-6 deficiency?

<p>dermatitis, anemia, seizures, depression, and confusion</p> Signup and view all the answers

What is the adult UL for vitamin B-6?

<p>100 mg/day</p> Signup and view all the answers

What is the role of tetrahydrofolate (THF) in the body?

<p>THF accepts a single-carbon group and participates in DNA synthesis and amino acid metabolism.</p> Signup and view all the answers

What is the main form of folate in the bloodstream?

<p>5-methyltetrahydrofolate (5-MTHF)</p> Signup and view all the answers

Why is folate essential for cell division?

<p>Folate is necessary for DNA synthesis, as cells need THF to make DNA.</p> Signup and view all the answers

What is the approximate riboflavin intake per day for adult American women and men?

<p>1.8 mg/day for women, 2.5 mg/day for men</p> Signup and view all the answers

What is the significance of the yellow color of urine when taking dietary supplements containing riboflavin?

<p>The excess riboflavin is excreted by the kidneys, causing the urine to turn yellow.</p> Signup and view all the answers

How much tryptophan is required to synthesize 1 mg of niacin in the body?

<p>About 60 mg of tryptophan</p> Signup and view all the answers

Why are people who eat corn as their staple food prone to develop pellagra?

<p>The niacin in corn is tightly bound to a protein that resists digestion.</p> Signup and view all the answers

What is the adult RDA for niacin in the US?

<p>14 mg/day for women, 16 mg/day for men</p> Signup and view all the answers

What are the classic signs and symptoms of pellagra?

<p>Dermatitis, diarrhea, dementia, and death (the '4 Ds of pellagra')</p> Signup and view all the answers

What is the adult UL for niacin in the US?

<p>35 mg/day</p> Signup and view all the answers

Why are people with alcoholism at risk of niacin deficiency?

<p>Disrupted tryptophan metabolism</p> Signup and view all the answers

What is the significance of limewater in the preparation of corn?

<p>It helps free the niacin, making it more absorbable.</p> Signup and view all the answers

Why are corn products like hominy and grits good sources of niacin?

<p>They have been treated with limewater before cooking.</p> Signup and view all the answers

What is the concern of taking folic acid supplements and consuming foods that contain the micronutrient?

<p>Excess folic acid may accumulate in blood and produce negative health effects.</p> Signup and view all the answers

Why does a pregnant woman have an increased requirement for folate?

<p>Because DNA synthesis and cell division take place at a rapid pace during embryonic development.</p> Signup and view all the answers

What are the two most common neural tube defects?

<p>Spina bifida and anencephaly.</p> Signup and view all the answers

What is the result of inadequate folic acid intake before and during early pregnancy?

<p>Increased risk of neural tube defects such as spina bifida and anencephaly.</p> Signup and view all the answers

What is the role of the enzyme methylenetetrahydrofolate reductase (MTHFR) in folate metabolism?

<p>It converts MTHF to the biologically active form of folate (5-MTHF).</p> Signup and view all the answers

Why are women with a defective MTHFR gene at risk of giving birth to a baby with neural tube defects?

<p>Because they may not be able to produce enough 5-MTHF for DNA production.</p> Signup and view all the answers

What is the significance of the neural tube in embryonic development?

<p>It eventually develops into the brain and spinal cord.</p> Signup and view all the answers

What is the recommended daily intake of folic acid for women capable of becoming pregnant?

<p>400 mcg of folic acid daily.</p> Signup and view all the answers

What is the consequence of a buildup of homocysteine in the bloodstream?

<p>Increased risk of cardiovascular disease (CVD).</p> Signup and view all the answers

Why is folic acid supplementation important for pregnant women?

<p>It can prevent many cases of neural tube defects.</p> Signup and view all the answers

What is the unique function of vitamin B-12 that is not related to folate?

<p>Maintaining the myelin sheaths that wrap around certain nerve cells, insulating them</p> Signup and view all the answers

What is the result of vitamin B-12 deficiency in the absence of treatment?

<p>Death</p> Signup and view all the answers

How long can a healthy liver's vitamin B-12 reserves last?

<p>5 to 10 years</p> Signup and view all the answers

What is the RDA for vitamin B-12 in adults?

<p>2.4 mcg/day</p> Signup and view all the answers

What percentage of Americans have a vitamin B-12 deficiency?

<p>15%</p> Signup and view all the answers

What is the primary source of vitamin B-12 in the typical American diet?

<p>Animal foods</p> Signup and view all the answers

What is the function of intrinsic factor in vitamin B-12 absorption?

<p>Binding vitamin B-12 in the small intestine</p> Signup and view all the answers

Why is it necessary for young women to take a daily multivitamin supplement containing folic acid?

<p>To prepare for pregnancy</p> Signup and view all the answers

What is the characteristic of red blood cells in individuals with vitamin B-12 deficiency?

<p>Megaloblastic</p> Signup and view all the answers

What is the result of the destruction of myelin sheaths in vitamin B-12 deficiency?

<p>Paralysis</p> Signup and view all the answers

What is the primary cause of most cases of vitamin B-12 deficiency?

<p>Problems that interfere with intestinal absorption of the vitamin, not inadequate intakes.</p> Signup and view all the answers

What is the condition that occurs when the cells in the stomach that produce intrinsic factor are destroyed?

<p>Pernicious anemia</p> Signup and view all the answers

Why do vegans need to be concerned about their vitamin B-12 intake?

<p>Because plant foods supply little vitamin B-12</p> Signup and view all the answers

What is the potential consequence for babies born to vegan mothers who do not supplement with vitamin B-12 during pregnancy?

<p>Megaloblastic anemia and serious nervous system problems</p> Signup and view all the answers

What is the nutrient that is a component of coenzyme A and critical for energy metabolism and fatty acid production?

<p>Pantothenic acid</p> Signup and view all the answers

What is a risk factor for pernicious anemia?

<p>Family history and advanced age</p> Signup and view all the answers

How can people with food-cobalamin malabsorption absorb synthetic forms of vitamin B-12?

<p>Through dietary supplements</p> Signup and view all the answers

What is the result of taking large doses of vitamin B-12 in individuals with pernicious anemia?

<p>A small amount of the vitamin is absorbed without the need for intrinsic factor</p> Signup and view all the answers

Why is HCl production in the stomach important for vitamin B-12 absorption?

<p>It helps release vitamin B-12 from animal protein</p> Signup and view all the answers

What is the common characteristic of people who are at risk for developing vitamin B-12 deficiency?

<p>Impaired absorption of the vitamin</p> Signup and view all the answers

What are the signs and symptoms of pantothenic acid deficiency?

<p>Headache, fatigue, impaired muscle coordination, and GI tract disturbances.</p> Signup and view all the answers

Why do people who consume raw eggs regularly for long periods of time may develop signs of biotin deficiency?

<p>Because avidin, a protein in raw egg whites, binds to biotin, making the vitamin resist digestion.</p> Signup and view all the answers

What is the role of vitamin C in collagen synthesis?

<p>Vitamin C helps create numerous cross-connections between the amino acids in collagen, greatly strengthening the connective tissue.</p> Signup and view all the answers

What is the result of vitamin C deficiency?

<p>Swollen gums that bleed easily, teeth that loosen and fall out of their sockets, skin that bruises easily, and poor wound healing.</p> Signup and view all the answers

Why may taking megadoses of vitamin C be wasteful?

<p>Because the kidneys increase their excretion of the vitamin in response to high intakes, and the small intestine absorbs less of the micronutrient when intakes exceed 200 mg/day.</p> Signup and view all the answers

What is the effect of conditons that reduce intestinal bacteria's biotin production on biotin deficiency?

<p>It can contribute to a biotin deficiency.</p> Signup and view all the answers

Why are humans and guinea pigs unable to make vitamin C?

<p>Because they are among the few species that are unable to synthesize all the vitamin they need.</p> Signup and view all the answers

What is the role of vitamin C as an antioxidant?

<p>It donates electrons to other compounds.</p> Signup and view all the answers

Why are people who abuse alcohol more likely to develop pantothenic acid and other B-vitamin deficiencies?

<p>Because their diets are often lacking in other nutrients as well.</p> Signup and view all the answers

What is the significance of collagen in the body?

<p>It gives strength to connective tissue, supporting other structures in the body.</p> Signup and view all the answers

What is the mechanism by which vitamin C acts as an antioxidant, and how does it recycle vitamin E?

<p>Vitamin C acts as an antioxidant by donating electrons to radicals. It also donates electrons to vitamin E, recycling it so that it can regain its antioxidant function.</p> Signup and view all the answers

What are some of the other roles of vitamin C in the body beyond its antioxidant function?

<p>Vitamin C plays a role in immune function, synthesis of bile and certain neurotransmitters, and production of hormones such as cortisol and thyroxin.</p> Signup and view all the answers

What are some of the best dietary sources of vitamin C?

<p>Plant foods such as peppers, citrus fruits, papaya, broccoli, and berries are rich in vitamin C. Potatoes and fortified foods like fruit drinks and cereals are also good sources.</p> Signup and view all the answers

Why is vitamin C unstable in certain conditions, and how can it be preserved?

<p>Vitamin C is unstable in the presence of heat, oxygen, light, alkaline conditions, and minerals like iron and copper. It can be preserved by storing foods in cool conditions, such as in the refrigerator.</p> Signup and view all the answers

What are the recommended daily intake and upper limit of vitamin C for adults?

<p>The adult RDA for vitamin C is 75-90 mg/day for women and men, respectively. The UL is 2000 mg/day, beyond which gastrointestinal upsets and other negative effects may occur.</p> Signup and view all the answers

Why do cigarette smokers and 'passive smokers' require higher amounts of vitamin C?

<p>Cigarette smoke increases radical formation in the lungs, making higher amounts of vitamin C necessary to offset this effect. Passive smokers may also require more vitamin C, although the exact amount is not established.</p> Signup and view all the answers

What is the potential risk of excessive oxalate excretion, and who may be affected?

<p>Excessive oxalate excretion can increase the risk of kidney stones. People susceptible to kidney stones should avoid consuming high amounts of vitamin C supplements.</p> Signup and view all the answers

Why is it unlikely that healthy people will develop a vitamin C deficiency, even if they do not take supplements?

<p>Most people require less than 10 mg of vitamin C daily to prevent scurvy, and a balanced diet can provide adequate amounts.</p> Signup and view all the answers

What happens to excess vitamin C in the body, and why is taking megadoses of supplements wasteful?

<p>When cells are saturated with vitamin C, the excess is filtered and eliminated in urine by the kidneys. Taking megadoses is wasteful because high amounts are not well absorbed and are eliminated in urine and feces.</p> Signup and view all the answers

Why is guava a valuable fruit, and what are some of its nutritional benefits?

<p>Guava is a valuable fruit because it is an excellent source of fiber and vitamin C. The white or pink flesh of a guava contains more vitamin C than an orange.</p> Signup and view all the answers

What is the primary function of vitamin C in the body, and why do Americans rarely develop scurvy?

<p>Vitamin C is essential for various bodily functions, and Americans rarely develop scurvy because it is added to many processed foods, including fruit and sports drinks, ready-to-eat cereals, and nutrition or power bars.</p> Signup and view all the answers

What are the richest sources of choline, and what is the adult AI for choline?

<p>The richest sources of choline are liver, wheat germ, eggs, beef, and pork. The adult AI for choline is 425 mg/day for women and 550 mg/day for men.</p> Signup and view all the answers

How does the body obtain choline, and why may vegans be at risk of choline deficiency?

<p>The body can obtain choline from dietary sources and also synthesize it from serine, an amino acid. Vegans may be at risk of choline deficiency because they do not eat animal-based foods, which are rich in choline.</p> Signup and view all the answers

What is the consequence of choline deficiency, and why is it a concern?

<p>Choline deficiency can cause liver damage. It is a concern because the body cannot produce enough choline, especially during certain life stages, and vegans may not consume enough choline from plant-based sources.</p> Signup and view all the answers

Why is it important to consider the amount of vitamin C in a supplement, and what is the recommended intake?

<p>It is important to consider the amount of vitamin C in a supplement because high doses can be unnecessary and may interact with other nutrients. The recommended intake is up to 200 mg per tablet.</p> Signup and view all the answers

What is the significance of lecithin in egg yolks, and what is its relation to choline?

<p>Lecithin is a phospholipid in egg yolks that is a rich source of choline. Choline is an essential nutrient that can be obtained from lecithin in egg yolks.</p> Signup and view all the answers

How does 5-MTHF work with vitamin B-12 to form the essential amino acid methionine?

<p>5-MTHF transfers a CH3 group to vitamin B-12, which then transfers the CH3 group to homocysteine, forming methionine.</p> Signup and view all the answers

What is the effect of vitamin B-12 deficiency on folate, even with adequate dietary intake?

<p>Folate cannot be used, leading to a deficiency, even with adequate dietary intake.</p> Signup and view all the answers

What is the difference in absorption between naturally occurring folate and synthetic folic acid?

<p>Synthetic folic acid is better absorbed than naturally occurring forms of folate.</p> Signup and view all the answers

What percentage of folate can be destroyed during food processing and preparation?

<p>50 to 90%</p> Signup and view all the answers

What is the recommended dietary allowance (RDA) for folate in adults?

<p>400 mcg (DFE)/day</p> Signup and view all the answers

What is the effect of folate deficiency on red blood cells?

<p>Megaloblastic anemia, characterized by large, immature RBCs with nuclei that do not carry normal amounts of oxygen.</p> Signup and view all the answers

Why do folate and vitamin B-12 deficiencies produce similar deficiency signs and symptoms?

<p>Many of folate's metabolic roles are related to those of vitamin B-12.</p> Signup and view all the answers

What is the tolerable upper intake level (UL) for synthetic folic acid?

<p>1000 mcg/day</p> Signup and view all the answers

Why is it important to determine which vitamin is lacking in cases of megaloblastic anemia?

<p>Because folate and vitamin B-12 deficiencies produce similar deficiency signs and symptoms.</p> Signup and view all the answers

What is the advantage of consuming fresh fruits and raw or lightly cooked vegetables in terms of folate content?

<p>You are likely to obtain most of the food's folate content, as folate is susceptible to destruction by heat, oxidation, and UV light.</p> Signup and view all the answers

Study Notes

Water-Soluble Vitamins

  • Coenzymes are small, organic molecules that interact with enzymes and regulate chemical reactions in the body.
  • Most water-soluble vitamins function as components of specific coenzymes.
  • B vitamins, such as thiamin, riboflavin, niacin, vitamin B-6, and pantothenic acid, function as part of coenzymes involved in energy metabolism.

Thiamin (Vitamin B1)

  • Thiamin is used to make a coenzyme that participates in chemical reactions involved in the release of energy from carbohydrates.
  • It plays a role in the metabolism of certain amino acids and may be necessary for the synthesis of neurotransmitters.
  • Food sources: whole-grain and enriched breads and cereals, pork, nuts, legumes, and orange juice.
  • RDA: 1.1-1.2 mg/day.
  • No reports of toxicity from consuming high amounts of thiamin from food or supplements.
  • Deficiency disease: beriberi, characterized by weakness and poor muscular coordination.
  • Severe lack of thiamin negatively affects the functioning of the cardiovascular, digestive, and nervous systems.

Riboflavin (Vitamin B2)

  • Riboflavin is a component of two coenzymes that play key roles in the metabolism of carbohydrates, lipids, and amino acids.
  • Food sources: milk, yogurt, and other milk products; enriched cereals; and liver.
  • RDA: 1.1-1.3 mg/day.
  • No UL established, as excess riboflavin is not well absorbed by the intestinal tract.
  • Deficiency symptoms: fatigue, inflammation of the mouth and tongue, and eye disorders.

Niacin (Vitamin B3)

  • Niacin is used to synthesize two coenzymes that participate in at least 200 reactions, including those involved in the release of energy from macronutrients.
  • Food sources: enriched cereals, beef liver, tuna, salmon, poultry, pork, and mushrooms.
  • RDA: 14-16 mg/day.
  • UL: 35 mg/day.
  • Deficiency disease: pellagra, characterized by dermatitis, diarrhea, dementia, and death.
  • Early signs and symptoms of mild niacin deficiency: poor appetite, weight loss, and weakness.

Vitamin B-6

  • Vitamin B-6 is required for the synthesis of neurotransmitters, such as serotonin and dopamine.
  • Food sources: liver, meat, fish, poultry, potatoes, bananas, spinach, sweet red peppers, and broccoli.
  • RDA: 1.3-1.7 mg/day.
  • UL: 100 mg/day.
  • Deficiency symptoms: dermatitis, anemia, seizures, depression, and confusion.

Folate (Vitamin B9)

  • Folate is the name for a group of related compounds, including folate in foods and folic acid.
  • Folate is converted to a coenzyme called tetrahydrofolate (THF), which participates in many chemical reactions involved in DNA synthesis and amino acid metabolism.
  • Food sources: leafy vegetables, liver, legumes, asparagus, broccoli, and orange juice.
  • RDA: 400 mcg (DFE)/day.
  • Deficiency symptoms: megaloblastic anemia, diarrhea, and neural tube defects in embryos.

Choline

  • Choline is needed for neurotransmitter and phospholipid synthesis, and methionine metabolism.
  • Food sources: widely distributed in foods and human biosynthesis.
  • RDA: 425-550 mg.
  • UL: not determined.
  • Deficiency symptoms: liver damage, and fishy body odor and reduced blood pressure.### Folate (Vitamin B9)
  • Folate is essential for DNA synthesis and cell division
  • Precursor cells that mature into RBCs must actively synthesize DNA, which requires folate
  • Without folate, precursor cells in bone marrow enlarge but cannot divide normally, leading to megaloblastic anemia
  • Megaloblastic anemia is characterized by large, immature RBCs with nuclei that do not carry normal amounts of oxygen
  • Folate deficiency can cause megaloblastic anemia, which can be cured by folic acid supplementation, but not the serious nervous system damage that accompanies vitamin B-12 deficiency
  • UL for synthetic folic acid is 1000 mcg/day to prevent masking of vitamin B-12 deficiency

Neural Tube Defects

  • Folate deficiency during pregnancy increases the risk of neural tube defects in the fetus
  • Women with folate deficiency are at risk of giving birth to infants with neural tube defects, such as spina bifida and anencephaly
  • Spina bifida occurs when the embryo's spine does not form properly, and the bones fail to enclose the spinal cord
  • Anencephaly occurs when much of the brain is malformed or missing
  • Folic acid intake before and during early pregnancy can prevent many cases of neural tube defects

Vitamin B-12

  • Vitamin B-12 is necessary for the transfer of CH3 groups in the metabolism of folate
  • Vitamin B-12 is required for the conversion of folate to coenzyme forms needed for DNA synthesis
  • Vitamin B-12 also participates in homocysteine metabolism and maintains the myelin sheaths that wrap around nerve cells
  • Vitamin B-12 deficiency can lead to nerve damage, megaloblastic RBCs, and death if left untreated
  • Food sources of vitamin B-12 include animal products, such as meat, milk, and eggs
  • Vegetarians and vegans are at risk of vitamin B-12 deficiency, but can consume fortified foods or supplements

Vitamin B-12 Deficiency

  • Vitamin B-12 deficiency can result from problems that interfere with intestinal absorption of the vitamin
  • Food-cobalamin malabsorption is a common cause of vitamin B-12 deficiency
  • Older adults are at risk of food-cobalamin malabsorption due to declining HCl production in the stomach
  • Certain medications, chronic alcoholism, and gastric bypass surgery can also contribute to food-cobalamin malabsorption
  • Pernicious anemia is an autoimmune disorder that causes inflammation and destruction of stomach cells that produce intrinsic factor, leading to vitamin B-12 deficiency

Pantothenic Acid

  • Pantothenic acid is a component of coenzyme A, which is critical for energy metabolism and fatty acid production
  • Pantothenic acid is widespread in foods, making a nutritional deficiency unlikely
  • Rich sources of pantothenic acid include cereals, liver, sunflower seeds, mushrooms, and soy milk
  • Deficiencies of pantothenic acid are rare, but may occur in people who abuse alcohol or have poor diets

Biotin

  • Biotin participates in chemical reactions that add carbon dioxide to other compounds
  • Biotin promotes the synthesis of glucose and fatty acids and the breakdown of certain amino acids
  • Severe deficiencies of biotin are rare, but may occur in people who consume raw eggs regularly or have conditions that reduce intestinal bacteria production
  • Signs and symptoms of biotin deficiency include skin rash, hair loss, seizures, and nervous system disorders

Vitamin C

  • Vitamin C is essential for humans and guinea pigs, which are unable to synthesize the vitamin

  • Vitamin C absorption occurs in the small intestine, but decreases as intakes increase

  • Vitamin C acts as an antioxidant, facilitates certain chemical reactions, and promotes collagen synthesis

  • Collagen synthesis requires vitamin C to form and maintain connective tissue

  • Vitamin C deficiency can cause scurvy, characterized by swollen gums, loose teeth, skin that bruises easily, and poor wound healing

  • Food sources of vitamin C include plant foods, such as peppers, citrus fruits, papaya, broccoli, and berries### Vitamin C

  • Passive smokers may need more than the RDA for vitamin C, but no specific amount has been recommended.

  • The adult UL for vitamin C is 2000 mg/day, exceeding this amount can cause gastrointestinal upsets, including diarrhea.

  • Taking megadoses of vitamin C supplements is wasteful since high amounts are not well absorbed and the excesses are eliminated in urine and feces.

  • Excess oxalate excretion may raise the risk of kidney stones, so individuals susceptible to kidney stones should avoid consuming vitamin C supplements.

  • Most people require less than 10 mg of vitamin C daily to prevent scurvy.

  • An 8-ounce serving of fresh orange juice provides about 80 mg of vitamin C, well beyond the requirement.

  • Americans rarely develop scurvy because vitamin C is added to many processed foods.

Choline

  • Choline is a vitamin-like nutrient necessary for producing phospholipids in cell membranes and acetylcholine, a neurotransmitter associated with learning and memory, muscle control, and many other nervous system functions.
  • Liver, wheat germ, eggs, beef, and pork are among the richest sources of choline.
  • The adult AI for choline is 425 mg/day (women) and 550 mg/day (men), but on average, adult Americans consume about 332 mg of choline per day.
  • The body can make choline from serine, an amino acid, but it cannot produce enough to meet the required amount, especially during some life stages.
  • Vegans may develop choline deficiency because they do not eat animal sources of food, leading to liver damage.

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Learn about the functions and sources of water-soluble vitamins, including their roles as coenzymes and health effects of excesses and deficiencies.

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