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Questions and Answers
What is the primary function of coenzymes in the body?
What is the primary function of coenzymes in the body?
To interact with enzymes and regulate chemical reactions.
What is the result of combining a B vitamin with a nitrogen-containing, nonprotein compound in the body?
What is the result of combining a B vitamin with a nitrogen-containing, nonprotein compound in the body?
The synthesis of a coenzyme.
What is the fate of coenzymes in food or supplements when consumed?
What is the fate of coenzymes in food or supplements when consumed?
They undergo digestion to release their B vitamin components.
Which B vitamins function as part of coenzymes involved in energy metabolism?
Which B vitamins function as part of coenzymes involved in energy metabolism?
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What is the purpose of cells removing free vitamins from the bloodstream?
What is the purpose of cells removing free vitamins from the bloodstream?
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Why is buying coenzyme supplements a waste of money?
Why is buying coenzyme supplements a waste of money?
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What is the role of coenzymes in synthesizing glucose, amino acids, and certain lipids?
What is the role of coenzymes in synthesizing glucose, amino acids, and certain lipids?
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What are the main functions of water-soluble vitamins in the body?
What are the main functions of water-soluble vitamins in the body?
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What is the major function of thiamin in the body?
What is the major function of thiamin in the body?
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What are the major dietary sources of riboflavin?
What are the major dietary sources of riboflavin?
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What is the major function of niacin in the body?
What is the major function of niacin in the body?
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What is the recommended daily intake of pantothenic acid for adults?
What is the recommended daily intake of pantothenic acid for adults?
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What is the major function of biotin in the body?
What is the major function of biotin in the body?
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What is the major function of vitamin B-6 in the body?
What is the major function of vitamin B-6 in the body?
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What is the major function of folate in the body?
What is the major function of folate in the body?
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What is the major function of vitamin B-12 in the body?
What is the major function of vitamin B-12 in the body?
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What is the major function of vitamin C in the body?
What is the major function of vitamin C in the body?
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What is the major function of choline in the body?
What is the major function of choline in the body?
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What is the primary function of thiamin in the body?
What is the primary function of thiamin in the body?
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What is the recommended daily intake of thiamin for adult men and women?
What is the recommended daily intake of thiamin for adult men and women?
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What is the name of the disease caused by a severe lack of thiamin?
What is the name of the disease caused by a severe lack of thiamin?
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What is the degenerative brain disorder associated with thiamin deficiency in the United States?
What is the degenerative brain disorder associated with thiamin deficiency in the United States?
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What is the role of riboflavin in metabolism?
What is the role of riboflavin in metabolism?
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Why should riboflavin-rich foods not be packaged or stored in clear glass containers?
Why should riboflavin-rich foods not be packaged or stored in clear glass containers?
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What is the recommended daily intake of riboflavin for adult men and women?
What is the recommended daily intake of riboflavin for adult men and women?
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What is the effect of cooking food in alkaline solutions on thiamin?
What is the effect of cooking food in alkaline solutions on thiamin?
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What are some good sources of thiamin?
What are some good sources of thiamin?
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What is the term for a chemical produced by a nerve cell that enables the cell to communicate with other nerve cells?
What is the term for a chemical produced by a nerve cell that enables the cell to communicate with other nerve cells?
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What side effects may occur in patients taking very high doses of niacin?,
What side effects may occur in patients taking very high doses of niacin?,
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What is the role of vitamin B-6 in the synthesis of neurotransmitters?
What is the role of vitamin B-6 in the synthesis of neurotransmitters?
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Why were babies in the 1950s experiencing irritability and seizures?
Why were babies in the 1950s experiencing irritability and seizures?
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What happens to vitamin B-6 during the refining process of grains?
What happens to vitamin B-6 during the refining process of grains?
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What is the range of the adult RDA for vitamin B-6?
What is the range of the adult RDA for vitamin B-6?
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What are the signs and symptoms of vitamin B-6 deficiency?
What are the signs and symptoms of vitamin B-6 deficiency?
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What is the adult UL for vitamin B-6?
What is the adult UL for vitamin B-6?
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What is the role of tetrahydrofolate (THF) in the body?
What is the role of tetrahydrofolate (THF) in the body?
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What is the main form of folate in the bloodstream?
What is the main form of folate in the bloodstream?
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Why is folate essential for cell division?
Why is folate essential for cell division?
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What is the approximate riboflavin intake per day for adult American women and men?
What is the approximate riboflavin intake per day for adult American women and men?
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What is the significance of the yellow color of urine when taking dietary supplements containing riboflavin?
What is the significance of the yellow color of urine when taking dietary supplements containing riboflavin?
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How much tryptophan is required to synthesize 1 mg of niacin in the body?
How much tryptophan is required to synthesize 1 mg of niacin in the body?
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Why are people who eat corn as their staple food prone to develop pellagra?
Why are people who eat corn as their staple food prone to develop pellagra?
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What is the adult RDA for niacin in the US?
What is the adult RDA for niacin in the US?
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What are the classic signs and symptoms of pellagra?
What are the classic signs and symptoms of pellagra?
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What is the adult UL for niacin in the US?
What is the adult UL for niacin in the US?
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Why are people with alcoholism at risk of niacin deficiency?
Why are people with alcoholism at risk of niacin deficiency?
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What is the significance of limewater in the preparation of corn?
What is the significance of limewater in the preparation of corn?
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Why are corn products like hominy and grits good sources of niacin?
Why are corn products like hominy and grits good sources of niacin?
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What is the concern of taking folic acid supplements and consuming foods that contain the micronutrient?
What is the concern of taking folic acid supplements and consuming foods that contain the micronutrient?
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Why does a pregnant woman have an increased requirement for folate?
Why does a pregnant woman have an increased requirement for folate?
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What are the two most common neural tube defects?
What are the two most common neural tube defects?
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What is the result of inadequate folic acid intake before and during early pregnancy?
What is the result of inadequate folic acid intake before and during early pregnancy?
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What is the role of the enzyme methylenetetrahydrofolate reductase (MTHFR) in folate metabolism?
What is the role of the enzyme methylenetetrahydrofolate reductase (MTHFR) in folate metabolism?
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Why are women with a defective MTHFR gene at risk of giving birth to a baby with neural tube defects?
Why are women with a defective MTHFR gene at risk of giving birth to a baby with neural tube defects?
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What is the significance of the neural tube in embryonic development?
What is the significance of the neural tube in embryonic development?
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What is the recommended daily intake of folic acid for women capable of becoming pregnant?
What is the recommended daily intake of folic acid for women capable of becoming pregnant?
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What is the consequence of a buildup of homocysteine in the bloodstream?
What is the consequence of a buildup of homocysteine in the bloodstream?
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Why is folic acid supplementation important for pregnant women?
Why is folic acid supplementation important for pregnant women?
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What is the unique function of vitamin B-12 that is not related to folate?
What is the unique function of vitamin B-12 that is not related to folate?
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What is the result of vitamin B-12 deficiency in the absence of treatment?
What is the result of vitamin B-12 deficiency in the absence of treatment?
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How long can a healthy liver's vitamin B-12 reserves last?
How long can a healthy liver's vitamin B-12 reserves last?
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What is the RDA for vitamin B-12 in adults?
What is the RDA for vitamin B-12 in adults?
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What percentage of Americans have a vitamin B-12 deficiency?
What percentage of Americans have a vitamin B-12 deficiency?
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What is the primary source of vitamin B-12 in the typical American diet?
What is the primary source of vitamin B-12 in the typical American diet?
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What is the function of intrinsic factor in vitamin B-12 absorption?
What is the function of intrinsic factor in vitamin B-12 absorption?
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Why is it necessary for young women to take a daily multivitamin supplement containing folic acid?
Why is it necessary for young women to take a daily multivitamin supplement containing folic acid?
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What is the characteristic of red blood cells in individuals with vitamin B-12 deficiency?
What is the characteristic of red blood cells in individuals with vitamin B-12 deficiency?
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What is the result of the destruction of myelin sheaths in vitamin B-12 deficiency?
What is the result of the destruction of myelin sheaths in vitamin B-12 deficiency?
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What is the primary cause of most cases of vitamin B-12 deficiency?
What is the primary cause of most cases of vitamin B-12 deficiency?
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What is the condition that occurs when the cells in the stomach that produce intrinsic factor are destroyed?
What is the condition that occurs when the cells in the stomach that produce intrinsic factor are destroyed?
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Why do vegans need to be concerned about their vitamin B-12 intake?
Why do vegans need to be concerned about their vitamin B-12 intake?
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What is the potential consequence for babies born to vegan mothers who do not supplement with vitamin B-12 during pregnancy?
What is the potential consequence for babies born to vegan mothers who do not supplement with vitamin B-12 during pregnancy?
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What is the nutrient that is a component of coenzyme A and critical for energy metabolism and fatty acid production?
What is the nutrient that is a component of coenzyme A and critical for energy metabolism and fatty acid production?
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What is a risk factor for pernicious anemia?
What is a risk factor for pernicious anemia?
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How can people with food-cobalamin malabsorption absorb synthetic forms of vitamin B-12?
How can people with food-cobalamin malabsorption absorb synthetic forms of vitamin B-12?
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What is the result of taking large doses of vitamin B-12 in individuals with pernicious anemia?
What is the result of taking large doses of vitamin B-12 in individuals with pernicious anemia?
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Why is HCl production in the stomach important for vitamin B-12 absorption?
Why is HCl production in the stomach important for vitamin B-12 absorption?
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What is the common characteristic of people who are at risk for developing vitamin B-12 deficiency?
What is the common characteristic of people who are at risk for developing vitamin B-12 deficiency?
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What are the signs and symptoms of pantothenic acid deficiency?
What are the signs and symptoms of pantothenic acid deficiency?
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Why do people who consume raw eggs regularly for long periods of time may develop signs of biotin deficiency?
Why do people who consume raw eggs regularly for long periods of time may develop signs of biotin deficiency?
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What is the role of vitamin C in collagen synthesis?
What is the role of vitamin C in collagen synthesis?
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What is the result of vitamin C deficiency?
What is the result of vitamin C deficiency?
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Why may taking megadoses of vitamin C be wasteful?
Why may taking megadoses of vitamin C be wasteful?
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What is the effect of conditons that reduce intestinal bacteria's biotin production on biotin deficiency?
What is the effect of conditons that reduce intestinal bacteria's biotin production on biotin deficiency?
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Why are humans and guinea pigs unable to make vitamin C?
Why are humans and guinea pigs unable to make vitamin C?
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What is the role of vitamin C as an antioxidant?
What is the role of vitamin C as an antioxidant?
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Why are people who abuse alcohol more likely to develop pantothenic acid and other B-vitamin deficiencies?
Why are people who abuse alcohol more likely to develop pantothenic acid and other B-vitamin deficiencies?
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What is the significance of collagen in the body?
What is the significance of collagen in the body?
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What is the mechanism by which vitamin C acts as an antioxidant, and how does it recycle vitamin E?
What is the mechanism by which vitamin C acts as an antioxidant, and how does it recycle vitamin E?
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What are some of the other roles of vitamin C in the body beyond its antioxidant function?
What are some of the other roles of vitamin C in the body beyond its antioxidant function?
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What are some of the best dietary sources of vitamin C?
What are some of the best dietary sources of vitamin C?
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Why is vitamin C unstable in certain conditions, and how can it be preserved?
Why is vitamin C unstable in certain conditions, and how can it be preserved?
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What are the recommended daily intake and upper limit of vitamin C for adults?
What are the recommended daily intake and upper limit of vitamin C for adults?
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Why do cigarette smokers and 'passive smokers' require higher amounts of vitamin C?
Why do cigarette smokers and 'passive smokers' require higher amounts of vitamin C?
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What is the potential risk of excessive oxalate excretion, and who may be affected?
What is the potential risk of excessive oxalate excretion, and who may be affected?
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Why is it unlikely that healthy people will develop a vitamin C deficiency, even if they do not take supplements?
Why is it unlikely that healthy people will develop a vitamin C deficiency, even if they do not take supplements?
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What happens to excess vitamin C in the body, and why is taking megadoses of supplements wasteful?
What happens to excess vitamin C in the body, and why is taking megadoses of supplements wasteful?
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Why is guava a valuable fruit, and what are some of its nutritional benefits?
Why is guava a valuable fruit, and what are some of its nutritional benefits?
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What is the primary function of vitamin C in the body, and why do Americans rarely develop scurvy?
What is the primary function of vitamin C in the body, and why do Americans rarely develop scurvy?
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What are the richest sources of choline, and what is the adult AI for choline?
What are the richest sources of choline, and what is the adult AI for choline?
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How does the body obtain choline, and why may vegans be at risk of choline deficiency?
How does the body obtain choline, and why may vegans be at risk of choline deficiency?
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What is the consequence of choline deficiency, and why is it a concern?
What is the consequence of choline deficiency, and why is it a concern?
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Why is it important to consider the amount of vitamin C in a supplement, and what is the recommended intake?
Why is it important to consider the amount of vitamin C in a supplement, and what is the recommended intake?
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What is the significance of lecithin in egg yolks, and what is its relation to choline?
What is the significance of lecithin in egg yolks, and what is its relation to choline?
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How does 5-MTHF work with vitamin B-12 to form the essential amino acid methionine?
How does 5-MTHF work with vitamin B-12 to form the essential amino acid methionine?
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What is the effect of vitamin B-12 deficiency on folate, even with adequate dietary intake?
What is the effect of vitamin B-12 deficiency on folate, even with adequate dietary intake?
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What is the difference in absorption between naturally occurring folate and synthetic folic acid?
What is the difference in absorption between naturally occurring folate and synthetic folic acid?
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What percentage of folate can be destroyed during food processing and preparation?
What percentage of folate can be destroyed during food processing and preparation?
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What is the recommended dietary allowance (RDA) for folate in adults?
What is the recommended dietary allowance (RDA) for folate in adults?
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What is the effect of folate deficiency on red blood cells?
What is the effect of folate deficiency on red blood cells?
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Why do folate and vitamin B-12 deficiencies produce similar deficiency signs and symptoms?
Why do folate and vitamin B-12 deficiencies produce similar deficiency signs and symptoms?
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What is the tolerable upper intake level (UL) for synthetic folic acid?
What is the tolerable upper intake level (UL) for synthetic folic acid?
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Why is it important to determine which vitamin is lacking in cases of megaloblastic anemia?
Why is it important to determine which vitamin is lacking in cases of megaloblastic anemia?
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What is the advantage of consuming fresh fruits and raw or lightly cooked vegetables in terms of folate content?
What is the advantage of consuming fresh fruits and raw or lightly cooked vegetables in terms of folate content?
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Study Notes
Water-Soluble Vitamins
- Coenzymes are small, organic molecules that interact with enzymes and regulate chemical reactions in the body.
- Most water-soluble vitamins function as components of specific coenzymes.
- B vitamins, such as thiamin, riboflavin, niacin, vitamin B-6, and pantothenic acid, function as part of coenzymes involved in energy metabolism.
Thiamin (Vitamin B1)
- Thiamin is used to make a coenzyme that participates in chemical reactions involved in the release of energy from carbohydrates.
- It plays a role in the metabolism of certain amino acids and may be necessary for the synthesis of neurotransmitters.
- Food sources: whole-grain and enriched breads and cereals, pork, nuts, legumes, and orange juice.
- RDA: 1.1-1.2 mg/day.
- No reports of toxicity from consuming high amounts of thiamin from food or supplements.
- Deficiency disease: beriberi, characterized by weakness and poor muscular coordination.
- Severe lack of thiamin negatively affects the functioning of the cardiovascular, digestive, and nervous systems.
Riboflavin (Vitamin B2)
- Riboflavin is a component of two coenzymes that play key roles in the metabolism of carbohydrates, lipids, and amino acids.
- Food sources: milk, yogurt, and other milk products; enriched cereals; and liver.
- RDA: 1.1-1.3 mg/day.
- No UL established, as excess riboflavin is not well absorbed by the intestinal tract.
- Deficiency symptoms: fatigue, inflammation of the mouth and tongue, and eye disorders.
Niacin (Vitamin B3)
- Niacin is used to synthesize two coenzymes that participate in at least 200 reactions, including those involved in the release of energy from macronutrients.
- Food sources: enriched cereals, beef liver, tuna, salmon, poultry, pork, and mushrooms.
- RDA: 14-16 mg/day.
- UL: 35 mg/day.
- Deficiency disease: pellagra, characterized by dermatitis, diarrhea, dementia, and death.
- Early signs and symptoms of mild niacin deficiency: poor appetite, weight loss, and weakness.
Vitamin B-6
- Vitamin B-6 is required for the synthesis of neurotransmitters, such as serotonin and dopamine.
- Food sources: liver, meat, fish, poultry, potatoes, bananas, spinach, sweet red peppers, and broccoli.
- RDA: 1.3-1.7 mg/day.
- UL: 100 mg/day.
- Deficiency symptoms: dermatitis, anemia, seizures, depression, and confusion.
Folate (Vitamin B9)
- Folate is the name for a group of related compounds, including folate in foods and folic acid.
- Folate is converted to a coenzyme called tetrahydrofolate (THF), which participates in many chemical reactions involved in DNA synthesis and amino acid metabolism.
- Food sources: leafy vegetables, liver, legumes, asparagus, broccoli, and orange juice.
- RDA: 400 mcg (DFE)/day.
- Deficiency symptoms: megaloblastic anemia, diarrhea, and neural tube defects in embryos.
Choline
- Choline is needed for neurotransmitter and phospholipid synthesis, and methionine metabolism.
- Food sources: widely distributed in foods and human biosynthesis.
- RDA: 425-550 mg.
- UL: not determined.
- Deficiency symptoms: liver damage, and fishy body odor and reduced blood pressure.### Folate (Vitamin B9)
- Folate is essential for DNA synthesis and cell division
- Precursor cells that mature into RBCs must actively synthesize DNA, which requires folate
- Without folate, precursor cells in bone marrow enlarge but cannot divide normally, leading to megaloblastic anemia
- Megaloblastic anemia is characterized by large, immature RBCs with nuclei that do not carry normal amounts of oxygen
- Folate deficiency can cause megaloblastic anemia, which can be cured by folic acid supplementation, but not the serious nervous system damage that accompanies vitamin B-12 deficiency
- UL for synthetic folic acid is 1000 mcg/day to prevent masking of vitamin B-12 deficiency
Neural Tube Defects
- Folate deficiency during pregnancy increases the risk of neural tube defects in the fetus
- Women with folate deficiency are at risk of giving birth to infants with neural tube defects, such as spina bifida and anencephaly
- Spina bifida occurs when the embryo's spine does not form properly, and the bones fail to enclose the spinal cord
- Anencephaly occurs when much of the brain is malformed or missing
- Folic acid intake before and during early pregnancy can prevent many cases of neural tube defects
Vitamin B-12
- Vitamin B-12 is necessary for the transfer of CH3 groups in the metabolism of folate
- Vitamin B-12 is required for the conversion of folate to coenzyme forms needed for DNA synthesis
- Vitamin B-12 also participates in homocysteine metabolism and maintains the myelin sheaths that wrap around nerve cells
- Vitamin B-12 deficiency can lead to nerve damage, megaloblastic RBCs, and death if left untreated
- Food sources of vitamin B-12 include animal products, such as meat, milk, and eggs
- Vegetarians and vegans are at risk of vitamin B-12 deficiency, but can consume fortified foods or supplements
Vitamin B-12 Deficiency
- Vitamin B-12 deficiency can result from problems that interfere with intestinal absorption of the vitamin
- Food-cobalamin malabsorption is a common cause of vitamin B-12 deficiency
- Older adults are at risk of food-cobalamin malabsorption due to declining HCl production in the stomach
- Certain medications, chronic alcoholism, and gastric bypass surgery can also contribute to food-cobalamin malabsorption
- Pernicious anemia is an autoimmune disorder that causes inflammation and destruction of stomach cells that produce intrinsic factor, leading to vitamin B-12 deficiency
Pantothenic Acid
- Pantothenic acid is a component of coenzyme A, which is critical for energy metabolism and fatty acid production
- Pantothenic acid is widespread in foods, making a nutritional deficiency unlikely
- Rich sources of pantothenic acid include cereals, liver, sunflower seeds, mushrooms, and soy milk
- Deficiencies of pantothenic acid are rare, but may occur in people who abuse alcohol or have poor diets
Biotin
- Biotin participates in chemical reactions that add carbon dioxide to other compounds
- Biotin promotes the synthesis of glucose and fatty acids and the breakdown of certain amino acids
- Severe deficiencies of biotin are rare, but may occur in people who consume raw eggs regularly or have conditions that reduce intestinal bacteria production
- Signs and symptoms of biotin deficiency include skin rash, hair loss, seizures, and nervous system disorders
Vitamin C
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Vitamin C is essential for humans and guinea pigs, which are unable to synthesize the vitamin
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Vitamin C absorption occurs in the small intestine, but decreases as intakes increase
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Vitamin C acts as an antioxidant, facilitates certain chemical reactions, and promotes collagen synthesis
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Collagen synthesis requires vitamin C to form and maintain connective tissue
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Vitamin C deficiency can cause scurvy, characterized by swollen gums, loose teeth, skin that bruises easily, and poor wound healing
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Food sources of vitamin C include plant foods, such as peppers, citrus fruits, papaya, broccoli, and berries### Vitamin C
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Passive smokers may need more than the RDA for vitamin C, but no specific amount has been recommended.
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The adult UL for vitamin C is 2000 mg/day, exceeding this amount can cause gastrointestinal upsets, including diarrhea.
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Taking megadoses of vitamin C supplements is wasteful since high amounts are not well absorbed and the excesses are eliminated in urine and feces.
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Excess oxalate excretion may raise the risk of kidney stones, so individuals susceptible to kidney stones should avoid consuming vitamin C supplements.
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Most people require less than 10 mg of vitamin C daily to prevent scurvy.
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An 8-ounce serving of fresh orange juice provides about 80 mg of vitamin C, well beyond the requirement.
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Americans rarely develop scurvy because vitamin C is added to many processed foods.
Choline
- Choline is a vitamin-like nutrient necessary for producing phospholipids in cell membranes and acetylcholine, a neurotransmitter associated with learning and memory, muscle control, and many other nervous system functions.
- Liver, wheat germ, eggs, beef, and pork are among the richest sources of choline.
- The adult AI for choline is 425 mg/day (women) and 550 mg/day (men), but on average, adult Americans consume about 332 mg of choline per day.
- The body can make choline from serine, an amino acid, but it cannot produce enough to meet the required amount, especially during some life stages.
- Vegans may develop choline deficiency because they do not eat animal sources of food, leading to liver damage.
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Description
Learn about the functions and sources of water-soluble vitamins, including their roles as coenzymes and health effects of excesses and deficiencies.