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Questions and Answers
A geriatric patient weighing 38kg is prescribed voriconazole for aspergillosis. What is the maximum FDA-approved daily oral dose?
A geriatric patient weighing 38kg is prescribed voriconazole for aspergillosis. What is the maximum FDA-approved daily oral dose?
- 300mg (correct)
- 600mg
- 800mg
- 12mg/kg
Voriconazole is administered to a patient. Which instruction should be included when counseling the patient about the medication?
Voriconazole is administered to a patient. Which instruction should be included when counseling the patient about the medication?
- Administer the medication without regard to food.
- Take with food to increase absorption.
- Decrease water intake when taking this medication.
- Take the oral formulation at least one hour before or after meals. (correct)
A 65-year-old patient weighing 60 kg is prescribed IV voriconazole for a confirmed aspergillosis infection. What is the appropriate daily IV dosage?
A 65-year-old patient weighing 60 kg is prescribed IV voriconazole for a confirmed aspergillosis infection. What is the appropriate daily IV dosage?
- 720mg daily (correct)
- 800mg daily
- 600mg daily
- 300mg daily
A patient with normal renal function is prescribed voriconazole. Which of the following is correct?
A patient with normal renal function is prescribed voriconazole. Which of the following is correct?
Which of the following is the primary indication for voriconazole?
Which of the following is the primary indication for voriconazole?
Why is it important to administer oral voriconazole at least one hour before or after meals?
Why is it important to administer oral voriconazole at least one hour before or after meals?
A patient with a confirmed aspergillosis infection weighs 50kg. What is the appropriate maximum FDA-approved oral dosage of voriconazole per day?
A patient with a confirmed aspergillosis infection weighs 50kg. What is the appropriate maximum FDA-approved oral dosage of voriconazole per day?
Which of the following dosage adjustments is necessary for voriconazole?
Which of the following dosage adjustments is necessary for voriconazole?
A 70-year-old patient weighing 35 kg is prescribed voriconazole. What is the maximum FDA-approved oral daily dosage?
A 70-year-old patient weighing 35 kg is prescribed voriconazole. What is the maximum FDA-approved oral daily dosage?
A patient is prescribed voriconazole. Which route of administration allows for the highest dose?
A patient is prescribed voriconazole. Which route of administration allows for the highest dose?
Flashcards
Voriconazole
Voriconazole
An antifungal medication used primarily for treating Aspergillosis.
Aspergillosis
Aspergillosis
A fungal infection caused by Aspergillus species, often treated with Voriconazole.
Dosage for patients 40kg or more
Dosage for patients 40kg or more
12mg/kg/day IV and FDA approved 600mg/day PO; off-label up to 800mg/day.
Dosage for patients 40kg or less
Dosage for patients 40kg or less
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Administration guidelines
Administration guidelines
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Voriconazole formulation types
Voriconazole formulation types
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Voriconazole first-line use
Voriconazole first-line use
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Dosage for patients over 40kg
Dosage for patients over 40kg
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Dosage for patients under 40kg
Dosage for patients under 40kg
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Administration timing for PO
Administration timing for PO
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Study Notes
Voriconazole (Vfend) Administration
- Voriconazole is available as intravenous (IV), oral tablets, oral capsules, and oral liquid suspension.
- It's a first-line treatment for aspergillosis.
- Maximum recommended doses vary based on patient weight.
- Maximum Geriatric doses are possible.
Dosing for Adults (40kg or More)
- Intravenous (IV): 12mg/kg/day
- Oral (PO): FDA-approved maximum dose is 600mg/day, but doses up to 800mg/day have been used off-label.
Dosing for Adults (40kg or Less)
- Intravenous (IV): 12mg/kg/day
- Oral (PO): FDA-approved maximum dose is 300mg/day, but doses up to 800mg/day have been used off-label.
Administration Considerations
- Oral formulations should be given at least one hour before or after meals.
- No renal dose adjustment is typically needed, but CrCl should be considered for patients with certain kidney conditions.
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