Podcast
Questions and Answers
A patient weighing 65kg is prescribed voriconazole for aspergillosis. What is the maximum oral dose that is FDA approved?
A patient weighing 65kg is prescribed voriconazole for aspergillosis. What is the maximum oral dose that is FDA approved?
A 35kg patient is prescribed voriconazole. What is the appropriate maximum FDA approved daily oral dosage?
A 35kg patient is prescribed voriconazole. What is the appropriate maximum FDA approved daily oral dosage?
Voriconazole should be administered at which of the following times in relation to meals?
Voriconazole should be administered at which of the following times in relation to meals?
Which route of administration is available for Voriconazole?
Which route of administration is available for Voriconazole?
Signup and view all the answers
Which of the following best describes voriconazole's role in treating aspergillosis?
Which of the following best describes voriconazole's role in treating aspergillosis?
Signup and view all the answers
What is a crucial instruction to provide a patient regarding the timing of oral voriconazole administration in relation to meals?
What is a crucial instruction to provide a patient regarding the timing of oral voriconazole administration in relation to meals?
Signup and view all the answers
A patient with aspergillosis has a body weight of 35 kg. What is the maximum FDA-approved daily oral dosage of voriconazole for this patient?
A patient with aspergillosis has a body weight of 35 kg. What is the maximum FDA-approved daily oral dosage of voriconazole for this patient?
Signup and view all the answers
A geriatric patient weighing 50kg is prescribed voriconazole. Which of the following is the most important consideration when determining the appropriate dosage?
A geriatric patient weighing 50kg is prescribed voriconazole. Which of the following is the most important consideration when determining the appropriate dosage?
Signup and view all the answers
What is the significance of a patient's CrCl when administering voriconazole, and what adjustments should be made based on it?
What is the significance of a patient's CrCl when administering voriconazole, and what adjustments should be made based on it?
Signup and view all the answers
Besides tablets and IV, which of the following is another available formulation of voriconazole?
Besides tablets and IV, which of the following is another available formulation of voriconazole?
Signup and view all the answers
Flashcards
Voriconazole forms
Voriconazole forms
Available as IV, PO tablets, capsules, and liquid suspension.
Voriconazole indications
Voriconazole indications
First-line treatment for Aspergillosis.
Dosage for 40kg+ patients
Dosage for 40kg+ patients
12mg/kg/day IV, 600mg/day PO FDA approved, up to 800mg off-label.
Dosage for 40kg- patients
Dosage for 40kg- patients
Signup and view all the flashcards
PO administration advice
PO administration advice
Signup and view all the flashcards
Voriconazole maximum dosage for 40kg+
Voriconazole maximum dosage for 40kg+
Signup and view all the flashcards
Voriconazole maximum dosage for 40kg-
Voriconazole maximum dosage for 40kg-
Signup and view all the flashcards
IV dosage for all patients
IV dosage for all patients
Signup and view all the flashcards
PO administration timing
PO administration timing
Signup and view all the flashcards
Renal dose adjustment for Voriconazole
Renal dose adjustment for Voriconazole
Signup and view all the flashcards
Study Notes
Voriconazole (Vfend) Dosage and Administration
-
Voriconazole is available as intravenous (IV), oral tablets, oral capsules, and oral liquid suspension.
-
It's a first-line treatment for aspergillosis.
-
Maximum dosages vary based on patient weight:
- For patients weighing 40 kg or more:
- IV dosage: 12 mg/kg/day
- Oral dosage: FDA-approved maximum is 600 mg/day, but doses up to 800 mg/day have been used off-label.
- For patients weighing 40 kg or less:
- IV dosage: 12 mg/kg/day
- Oral dosage: FDA-approved maximum is 300 mg/day, but doses up to 800 mg/day have been used off-label.
- For patients weighing 40 kg or more:
-
Oral formulations should be given at least one hour before or after meals.
-
No renal dose adjustment is typically necessary; however, further consideration is needed if creatinine clearance (CrCl) is affected.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
This quiz covers the key dosage and administration guidelines for Voriconazole, a vital antifungal medication. Learn about the different formulations, maximum dosages based on patient weight, and special considerations for oral dosing. Perfect for healthcare professionals and students in medical fields.
