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Questions and Answers
A patient weighing 65kg is prescribed voriconazole for aspergillosis. What is the maximum oral dose that is FDA approved?
A patient weighing 65kg is prescribed voriconazole for aspergillosis. What is the maximum oral dose that is FDA approved?
- 800mg/day
- 12mg/kg/day
- 300mg/day
- 600mg/day (correct)
A 35kg patient is prescribed voriconazole. What is the appropriate maximum FDA approved daily oral dosage?
A 35kg patient is prescribed voriconazole. What is the appropriate maximum FDA approved daily oral dosage?
- 300mg (correct)
- 800mg
- 12mg/kg
- 600mg
Voriconazole should be administered at which of the following times in relation to meals?
Voriconazole should be administered at which of the following times in relation to meals?
- It does not matter in relation to meals
- At least one hour before or after meals (correct)
- Immediately after meals
- With meals
Which route of administration is available for Voriconazole?
Which route of administration is available for Voriconazole?
Which of the following best describes voriconazole's role in treating aspergillosis?
Which of the following best describes voriconazole's role in treating aspergillosis?
What is a crucial instruction to provide a patient regarding the timing of oral voriconazole administration in relation to meals?
What is a crucial instruction to provide a patient regarding the timing of oral voriconazole administration in relation to meals?
A patient with aspergillosis has a body weight of 35 kg. What is the maximum FDA-approved daily oral dosage of voriconazole for this patient?
A patient with aspergillosis has a body weight of 35 kg. What is the maximum FDA-approved daily oral dosage of voriconazole for this patient?
A geriatric patient weighing 50kg is prescribed voriconazole. Which of the following is the most important consideration when determining the appropriate dosage?
A geriatric patient weighing 50kg is prescribed voriconazole. Which of the following is the most important consideration when determining the appropriate dosage?
What is the significance of a patient's CrCl when administering voriconazole, and what adjustments should be made based on it?
What is the significance of a patient's CrCl when administering voriconazole, and what adjustments should be made based on it?
Besides tablets and IV, which of the following is another available formulation of voriconazole?
Besides tablets and IV, which of the following is another available formulation of voriconazole?
Flashcards
Voriconazole forms
Voriconazole forms
Available as IV, PO tablets, capsules, and liquid suspension.
Voriconazole indications
Voriconazole indications
First-line treatment for Aspergillosis.
Dosage for 40kg+ patients
Dosage for 40kg+ patients
12mg/kg/day IV, 600mg/day PO FDA approved, up to 800mg off-label.
Dosage for 40kg- patients
Dosage for 40kg- patients
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PO administration advice
PO administration advice
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Voriconazole maximum dosage for 40kg+
Voriconazole maximum dosage for 40kg+
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Voriconazole maximum dosage for 40kg-
Voriconazole maximum dosage for 40kg-
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IV dosage for all patients
IV dosage for all patients
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PO administration timing
PO administration timing
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Renal dose adjustment for Voriconazole
Renal dose adjustment for Voriconazole
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Study Notes
Voriconazole (Vfend) Dosage and Administration
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Voriconazole is available as intravenous (IV), oral tablets, oral capsules, and oral liquid suspension.
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It's a first-line treatment for aspergillosis.
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Maximum dosages vary based on patient weight:
- For patients weighing 40 kg or more:
- IV dosage: 12 mg/kg/day
- Oral dosage: FDA-approved maximum is 600 mg/day, but doses up to 800 mg/day have been used off-label.
- For patients weighing 40 kg or less:
- IV dosage: 12 mg/kg/day
- Oral dosage: FDA-approved maximum is 300 mg/day, but doses up to 800 mg/day have been used off-label.
- For patients weighing 40 kg or more:
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Oral formulations should be given at least one hour before or after meals.
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No renal dose adjustment is typically necessary; however, further consideration is needed if creatinine clearance (CrCl) is affected.
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