Viral Hepatitis: Key Concepts

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Questions and Answers

What does a prolonged prothrombin time (PT) typically indicate in the context of liver disease?

  • Low bilirubin levels
  • Impaired liver synthetic function (correct)
  • Excessive bile production
  • Normal clotting function

Which viral marker typically indicates immunity to hepatitis B following successful vaccination?

  • Anti-HBc IgG
  • HBsAg
  • HBeAg
  • Anti-HBs (correct)

What is the primary cause of jaundice in individuals with viral hepatitis?

  • Increased urea production
  • Decreased albumin synthesis
  • Reduced liver enzyme activity
  • Increased bilirubin production (correct)

Which condition is a significant and common complication associated with chronic hepatitis B or C infection?

<p>Cirrhosis (B)</p> Signup and view all the answers

In cases of viral hepatitis, which enzyme is most frequently found to be elevated in laboratory tests?

<p>Alanine aminotransferase (ALT) (B)</p> Signup and view all the answers

Which hepatitis virus is associated with the highest mortality rate among pregnant women?

<p>Hepatitis E (D)</p> Signup and view all the answers

A patient with liver disease has a prolonged prothrombin time. What direct consequence of this is most concerning?

<p>Increased risk of bleeding (D)</p> Signup and view all the answers

If a patient tests positive for anti-HBs after a hepatitis B vaccination, what does this result indicate?

<p>Immunity to Hepatitis B (B)</p> Signup and view all the answers

Besides liver damage, what other significant physiological process is directly affected by increased bilirubin production in viral hepatitis?

<p>Bile acid synthesis (B)</p> Signup and view all the answers

Why does chronic hepatitis B or C often lead to cirrhosis?

<p>Chronic inflammation and liver cell damage (C)</p> Signup and view all the answers

In viral hepatitis, why is ALT a more specific marker of liver damage than other enzymes found in the blood?

<p>It is mainly located in the liver cells (A)</p> Signup and view all the answers

What unique risk do pregnant women face with hepatitis E compared to non-pregnant individuals?

<p>Increased risk of fulminant hepatic failure (C)</p> Signup and view all the answers

What is the underlying mechanism that connects impaired liver synthetic function, prolonged prothrombin time, and increased risk of bleeding in liver disease?

<p>Decreased production of clotting factors (B)</p> Signup and view all the answers

If a patient presents with jaundice, elevated ALT, and a history of international travel, which type of hepatitis is most likely, and what initial test would confirm your suspicion?

<p>Hepatitis E; test for anti-HEV IgM (D)</p> Signup and view all the answers

In chronic hepatitis C infection leading to cirrhosis, what mechanism primarily contributes to portal hypertension and its complications?

<p>Fibrosis and scarring within the liver (D)</p> Signup and view all the answers

Why is it important to differentiate between various types of viral hepatitis (A, B, C, E) regarding prognosis and management strategies?

<p>Each type varies significantly in terms of chronicity, complications, and vaccine availability. (C)</p> Signup and view all the answers

How does an acute hepatitis A infection differ from a chronic hepatitis B infection in terms of long-term liver damage and risk of cirrhosis?

<p>Hepatitis A is typically self-limiting with no chronic carrier state, whereas hepatitis B can led to a chronic infection, cirrhosis, and hepatocellular carcinoma. (A)</p> Signup and view all the answers

In a liver transplant candidate with cirrhosis due to chronic hepatitis C, what is the key consideration to prevent recurrence of the virus post-transplantation?

<p>Initiating antiviral therapy to eradicate the virus before or immediately after the transplant (D)</p> Signup and view all the answers

Considering the possible complications of chronic viral hepatitis, what monitoring strategy is most important for early detection of hepatocellular carcinoma?

<p>Surveillance with ultrasound and alpha-fetoprotein (AFP) measurement (C)</p> Signup and view all the answers

Flashcards

Prolonged PT in liver disease

Prolonged prothrombin time in liver disease suggests impaired liver synthetic function.

Viral marker for Hepatitis B immunity

Anti-HBc IgG indicates immunity to hepatitis B due to previous infection.

Cause of jaundice in viral hepatitis

Jaundice in viral hepatitis results from increased bilirubin production.

Complication of chronic hepatitis B/C

Cirrhosis is a significant complication of chronic hepatitis B or C infection.

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Enzyme elevated in viral hepatitis

Alanine aminotransferase (ALT) is commonly elevated in viral hepatitis.

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Hepatitis with highest mortality in pregnancy

Hepatitis E virus has the highest mortality rate in pregnant women.

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Study Notes

  • Prolonged prothrombin time (PT) in liver disease indicates impaired liver synthetic function.
  • Anti-HBc IgG is the viral marker that indicates immunity to hepatitis B due to vaccination.
  • Jaundice in viral hepatitis occurs due to increased bilirubin production.
  • Cirrhosis is a significant complication of chronic hepatitis B or C infection.
  • Alanine aminotransferase (ALT) is the enzyme most commonly elevated in viral hepatitis.
  • Hepatitis E has the highest mortality rate in pregnant women among hepatitis viruses.

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