Viral Fusion Proteins Quiz
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Questions and Answers

What type of proteins are involved in mediating membrane fusion in viral infections?

  • Peripheral membrane proteins
  • Glycosylated membrane proteins
  • Type II transmembrane proteins
  • Type I transmembrane proteins (correct)

What is the role of fusion proteins in viral infection?

  • They are primarily involved in viral replication
  • They play a critical role in viral infection and can be therapeutic targets (correct)
  • They facilitate viral entry into the host cell
  • They are responsible for viral genome packaging

Which class of fusion proteins mostly tend to form trimers and have two distinct conformations?

  • Class III fusion proteins
  • Class I fusion proteins (correct)
  • Class II fusion proteins
  • Class IV fusion proteins

What type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

<p>Class II fusion proteins (B)</p> Signup and view all the answers

How do non-enveloped viruses penetrate host membranes?

<p>By membrane lysis or pore formation (B)</p> Signup and view all the answers

What triggers the loosening up of the capsid wall in non-enveloped viruses?

<p>Binding to receptor (D)</p> Signup and view all the answers

How do some virions/capsids get transported along microtubules?

<p>Using molecular motors like dynein (A)</p> Signup and view all the answers

Why do many DNA viruses use the nucleus as the site of replication?

<p>It is where the cellular machinery for transcription is located (C)</p> Signup and view all the answers

How do some viruses establish latency in the nucleus?

<p>By integrating their genome into the host genome (C)</p> Signup and view all the answers

What is a strategy used by viruses to pass through the nuclear membrane?

<p>Interacting with nuclear targeting receptors such as importins (D)</p> Signup and view all the answers

What is a potential target for antiviral drugs in the virus replication cycle?

<p>Uncoating of capsids (A)</p> Signup and view all the answers

What is a characteristic of coronaviruses' genome?

<p>Linear, single-stranded positive sense RNA (C)</p> Signup and view all the answers

Which family do coronaviruses belong to?

<p>Coronaviridae (A)</p> Signup and view all the answers

What is the function of the 5’ terminal cap in coronaviruses' genome?

<p>It resembles cellular RNAs (A)</p> Signup and view all the answers

What is the role of the first 2/3rd of the genome in coronaviruses?

<p>Translated into polyprotein (C)</p> Signup and view all the answers

What is a characteristic feature of Alpha-, beta-, and gammacoronaviruses?

<p>Highly conserved order of genes (A)</p> Signup and view all the answers

Which type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

<p>Class II fusion proteins (C)</p> Signup and view all the answers

What is the role of fusion proteins in viral infection?

<p>Induce conformational changes in the viral envelope protein (C)</p> Signup and view all the answers

What type of proteins are involved in mediating membrane fusion in viral infections?

<p>Type I transmembrane proteins (D)</p> Signup and view all the answers

What triggers the final trimer formation in class II fusion proteins?

<p>pH change (C)</p> Signup and view all the answers

Which of the following is a strategy used by some viruses to pass through the nuclear membrane?

<p>Partial disassembly in the cytoplasm and entry through nuclear pore (B)</p> Signup and view all the answers

What is a potential target for antiviral drugs in the virus replication cycle?

<p>Uncoating of capsids (C)</p> Signup and view all the answers

Which of the following is a characteristic feature of Alpha-, beta-, and gammacoronaviruses?

<p>Genome with 5’ terminal cap and 3’ poly (A) tail (D)</p> Signup and view all the answers

What triggers the loosening up of the capsid wall in non-enveloped viruses?

<p>Receptor binding (C)</p> Signup and view all the answers

What is the role of the 5’ terminal cap in coronaviruses' genome?

<p>Enhances translation efficiency (B)</p> Signup and view all the answers

What type of proteins are involved in mediating membrane fusion in viral infections?

<p>Class I fusogens (C)</p> Signup and view all the answers

What is the function of the first 2/3rd of the genome in coronaviruses?

<p>Translates into polyprotein (A)</p> Signup and view all the answers

How do some viruses establish latency in the nucleus?

<p>Integration into the host genome (C)</p> Signup and view all the answers

What type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

<p>Class II fusogens (C)</p> Signup and view all the answers

Why do many DNA viruses use the nucleus as the site of replication?

<p>To utilize the cellular machinery for transcription (C)</p> Signup and view all the answers

What triggers the final trimer formation in class II fusion proteins?

<p>Low pH in endosomes (B)</p> Signup and view all the answers

What is a characteristic of non-enveloped viruses' penetration of host membranes?

<p>Dependent on endocytosis (D)</p> Signup and view all the answers

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