Viral Fusion Proteins Quiz

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What type of proteins are involved in mediating membrane fusion in viral infections?

Peripheral membrane proteins

Glycosylated membrane proteins

Type II transmembrane proteins

Type I transmembrane proteins (correct)

What is the role of fusion proteins in viral infection?

They are primarily involved in viral replication

They play a critical role in viral infection and can be therapeutic targets (correct)

They facilitate viral entry into the host cell

They are responsible for viral genome packaging

Which class of fusion proteins mostly tend to form trimers and have two distinct conformations?

Class III fusion proteins

Class I fusion proteins (correct)

Class II fusion proteins

Class IV fusion proteins

What type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

Class II fusion proteins Signup and view all the answers

How do non-enveloped viruses penetrate host membranes?

By membrane lysis or pore formation Signup and view all the answers

What triggers the loosening up of the capsid wall in non-enveloped viruses?

Binding to receptor Signup and view all the answers

How do some virions/capsids get transported along microtubules?

Using molecular motors like dynein Signup and view all the answers

Why do many DNA viruses use the nucleus as the site of replication?

It is where the cellular machinery for transcription is located Signup and view all the answers

How do some viruses establish latency in the nucleus?

By integrating their genome into the host genome Signup and view all the answers

What is a strategy used by viruses to pass through the nuclear membrane?

Interacting with nuclear targeting receptors such as importins Signup and view all the answers

What is a potential target for antiviral drugs in the virus replication cycle?

Uncoating of capsids Signup and view all the answers

What is a characteristic of coronaviruses' genome?

Linear, single-stranded positive sense RNA Signup and view all the answers

Which family do coronaviruses belong to?

Coronaviridae Signup and view all the answers

What is the function of the 5’ terminal cap in coronaviruses' genome?

It resembles cellular RNAs Signup and view all the answers

What is the role of the first 2/3rd of the genome in coronaviruses?

Translated into polyprotein Signup and view all the answers

What is a characteristic feature of Alpha-, beta-, and gammacoronaviruses?

Highly conserved order of genes Signup and view all the answers

Which type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

Class II fusion proteins Signup and view all the answers

What is the role of fusion proteins in viral infection?

Induce conformational changes in the viral envelope protein Signup and view all the answers

What type of proteins are involved in mediating membrane fusion in viral infections?

Type I transmembrane proteins Signup and view all the answers

What triggers the final trimer formation in class II fusion proteins?

pH change Signup and view all the answers

Which of the following is a strategy used by some viruses to pass through the nuclear membrane?

Partial disassembly in the cytoplasm and entry through nuclear pore Signup and view all the answers

What is a potential target for antiviral drugs in the virus replication cycle?

Uncoating of capsids Signup and view all the answers

Which of the following is a characteristic feature of Alpha-, beta-, and gammacoronaviruses?

Genome with 5’ terminal cap and 3’ poly (A) tail Signup and view all the answers

What triggers the loosening up of the capsid wall in non-enveloped viruses?

Receptor binding Signup and view all the answers

What is the role of the 5’ terminal cap in coronaviruses' genome?

Enhances translation efficiency Signup and view all the answers

What type of proteins are involved in mediating membrane fusion in viral infections?

Class I fusogens Signup and view all the answers

What is the function of the first 2/3rd of the genome in coronaviruses?

Translates into polyprotein Signup and view all the answers

How do some viruses establish latency in the nucleus?

Integration into the host genome Signup and view all the answers

What type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

Class II fusogens Signup and view all the answers

Why do many DNA viruses use the nucleus as the site of replication?

To utilize the cellular machinery for transcription Signup and view all the answers

What triggers the final trimer formation in class II fusion proteins?

Low pH in endosomes Signup and view all the answers

What is a characteristic of non-enveloped viruses' penetration of host membranes?

Dependent on endocytosis Signup and view all the answers

Viral Fusion Proteins Quiz

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Questions and Answers

What type of proteins are involved in mediating membrane fusion in viral infections?

What is the role of fusion proteins in viral infection?

Which class of fusion proteins mostly tend to form trimers and have two distinct conformations?

What type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

How do non-enveloped viruses penetrate host membranes?

What triggers the loosening up of the capsid wall in non-enveloped viruses?

How do some virions/capsids get transported along microtubules?

Why do many DNA viruses use the nucleus as the site of replication?

How do some viruses establish latency in the nucleus?

What is a strategy used by viruses to pass through the nuclear membrane?

What is a potential target for antiviral drugs in the virus replication cycle?

What is a characteristic of coronaviruses' genome?

Which family do coronaviruses belong to?

What is the function of the 5’ terminal cap in coronaviruses' genome?

What is the role of the first 2/3rd of the genome in coronaviruses?

What is a characteristic feature of Alpha-, beta-, and gammacoronaviruses?

Which type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

What is the role of fusion proteins in viral infection?

What type of proteins are involved in mediating membrane fusion in viral infections?

What triggers the final trimer formation in class II fusion proteins?

Which of the following is a strategy used by some viruses to pass through the nuclear membrane?

What is a potential target for antiviral drugs in the virus replication cycle?

Which of the following is a characteristic feature of Alpha-, beta-, and gammacoronaviruses?

What triggers the loosening up of the capsid wall in non-enveloped viruses?

What is the role of the 5’ terminal cap in coronaviruses' genome?

What type of proteins are involved in mediating membrane fusion in viral infections?

What is the function of the first 2/3rd of the genome in coronaviruses?

How do some viruses establish latency in the nucleus?

What type of fusion proteins involve rearrangement of multimers of protein subunits and minor conformational changes at tertiary level?

Why do many DNA viruses use the nucleus as the site of replication?

What triggers the final trimer formation in class II fusion proteins?

What is a characteristic of non-enveloped viruses' penetration of host membranes?

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