Viral Fusion Proteins and Membrane Fusion Quiz
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Questions and Answers

Which cellular process is NOT essential for virus internalization/penetration?

  • Carboxylic ionophores
  • Preventing endosome acidification
  • Inhibiting cytoplasmic protein synthesis (correct)
  • Using lysosomotropic agents
  • What is a strategy for some viruses to pass through the nuclear membrane?

  • Directly fusing with the nuclear membrane
  • Interacting with importins and nuclear localization signals (correct)
  • Inducing nuclear pore disassembly
  • Utilizing lysosomotropic agents
  • Which type of viruses typically use the nucleus as a site of replication?

  • Retroviruses
  • RNA viruses
  • DNA viruses (correct)
  • Enveloped viruses
  • What is the function of neutralizing antibodies in preventing virus entry?

    <p>Preventing binding of the virion to receptors on cell surface</p> Signup and view all the answers

    Which type of antiviral drugs target a specific virus or a small range of viruses?

    <p>Narrow spectrum</p> Signup and view all the answers

    What is the primary structure of coronaviruses?

    <p>Single-stranded positive sense RNA genome</p> Signup and view all the answers

    What is the function of the trimeric spikes on coronaviruses?

    <p>Aid in virus attachment and entry into host cells</p> Signup and view all the answers

    Which cellular machinery is essential for DNA virus replication in the nucleus?

    <p>Machinery for transcription, RNA processing, and DNA replication</p> Signup and view all the answers

    What is the role of importins in virus entry into the nucleus?

    <p>Interacting with nuclear targeting receptors and nuclear localization signals</p> Signup and view all the answers

    Which type of antiviral drugs target a wide range of viruses?

    <p>Broad spectrum</p> Signup and view all the answers

    What is the primary structure of the viral genome of coronaviruses?

    <p>Linear, single-stranded positive sense RNA</p> Signup and view all the answers

    What is the role of the 5’ terminal cap and 3’ poly (A) tail in the viral genome of coronaviruses?

    <p>Enhance translation efficiency</p> Signup and view all the answers

    Which type of proteins are generally involved in mediating membrane fusion in viral infections?

    <p>Type I transmembrane proteins</p> Signup and view all the answers

    What is the role of cellular proteases in the maturation of fusion proteins?

    <p>Cleaved while transiting ER-Golgi to plasma membrane</p> Signup and view all the answers

    What happens to the fusion peptide during virus-induced membrane fusion?

    <p>Gets inserted into the target cellular membrane</p> Signup and view all the answers

    Which type of fusion proteins mostly tend to form trimers and have two distinct conformations perpendicular to the envelope surface and hairpin conformation after fusion?

    <p>Class I fusion proteins</p> Signup and view all the answers

    What type of fusion proteins involve rearrangement of multimers of protein subunits but only minor conformational changes at the tertiary level?

    <p>Class II fusion proteins</p> Signup and view all the answers

    Which type of fusion proteins generally consist of two subunits: fusion subunit and receptor binding subunit?

    <p>Class III fusion proteins</p> Signup and view all the answers

    What provides the energy for membrane fusion mediated by viral fusion proteins?

    <p>Conformation changes</p> Signup and view all the answers

    What is the main role of fusion proteins in viral infection?

    <p>Mediating membrane fusion</p> Signup and view all the answers

    What is the primary triggering event for fusion involving Class II fusion proteins?

    <p>pH change</p> Signup and view all the answers

    What type of fusion proteins are mostly alpha-helical and tend to form trimers?

    <p>Class I fusion proteins</p> Signup and view all the answers

    What is the characteristic structure of Class II fusion proteins?

    <p>Mostly beta-sheets, tend to form dimers</p> Signup and view all the answers

    What type of fusion proteins involve conformational changes that reveal a fusion peptide inserted into the target cellular membrane during virus-induced membrane fusion?

    <p>Class I fusion proteins</p> Signup and view all the answers

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