Questions and Answers
Which cellular process is NOT essential for virus internalization/penetration?
Inhibiting cytoplasmic protein synthesis
What is a strategy for some viruses to pass through the nuclear membrane?
Interacting with importins and nuclear localization signals
Which type of viruses typically use the nucleus as a site of replication?
DNA viruses
What is the function of neutralizing antibodies in preventing virus entry?
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Which type of antiviral drugs target a specific virus or a small range of viruses?
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What is the primary structure of coronaviruses?
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What is the function of the trimeric spikes on coronaviruses?
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Which cellular machinery is essential for DNA virus replication in the nucleus?
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What is the role of importins in virus entry into the nucleus?
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Which type of antiviral drugs target a wide range of viruses?
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What is the primary structure of the viral genome of coronaviruses?
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What is the role of the 5’ terminal cap and 3’ poly (A) tail in the viral genome of coronaviruses?
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Which type of proteins are generally involved in mediating membrane fusion in viral infections?
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What is the role of cellular proteases in the maturation of fusion proteins?
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What happens to the fusion peptide during virus-induced membrane fusion?
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Which type of fusion proteins mostly tend to form trimers and have two distinct conformations perpendicular to the envelope surface and hairpin conformation after fusion?
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What type of fusion proteins involve rearrangement of multimers of protein subunits but only minor conformational changes at the tertiary level?
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Which type of fusion proteins generally consist of two subunits: fusion subunit and receptor binding subunit?
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What provides the energy for membrane fusion mediated by viral fusion proteins?
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What is the main role of fusion proteins in viral infection?
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What is the primary triggering event for fusion involving Class II fusion proteins?
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What type of fusion proteins are mostly alpha-helical and tend to form trimers?
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What is the characteristic structure of Class II fusion proteins?
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What type of fusion proteins involve conformational changes that reveal a fusion peptide inserted into the target cellular membrane during virus-induced membrane fusion?
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