Viral Fusion Proteins Quiz

Which type of fusion protein tends to form dimers and involves rearrangement of multimers of protein subunits?

Class II fusion proteins

What type of conformational changes reveal a fusion peptide, which gets inserted into the target cellular membrane during virus-induced membrane fusion?

Conformational changes that reveal a fusion peptide

Which type of fusion protein tends to be mostly alpha-helical and forms trimers with two distinct conformations?

Class I fusion proteins

Where are fusion proteins synthesized, folded, and assembled before undergoing maturation?

Endoplasmic Reticulum (ER) Signup and view all the answers

Which cellular machinery is often utilized by viruses for transportation to the cytosol?

Microtubules Signup and view all the answers

What is a strategy used by viruses to pass through the nuclear membrane?

Interaction with importins Signup and view all the answers

What is a strategy for preventing virus entry?

Inhibit endosome acidification Signup and view all the answers

Which type of virus uses the nucleus as a site of replication, taking advantage of the cellular machinery for transcription?

DNA viruses Signup and view all the answers

What is the order of genes in coronaviruses based on genome homologies?

Alpha-, beta-, gamma- Signup and view all the answers

What type of RNA genome do coronaviruses possess?

Single-stranded positive sense RNA Signup and view all the answers

Where are the fusion proteins synthesized, folded, and assembled before undergoing maturation?

Cytoplasm Signup and view all the answers

What is the function of importins in virus entry into the nucleus?

Interact with nuclear targeting receptors Signup and view all the answers

What is the role of hydrophobic proteins in capsids during virus entry?

Create membrane channels followed by genome egress Signup and view all the answers

What is the primary function of neutralizing antibodies in preventing virus entry?

Prevent binding of the virion to receptors on cell surface Signup and view all the answers

What is the advantage of narrow spectrum antivirals?

They are effective against specific viruses Signup and view all the answers

What is the structure of coronaviruses?

Spherical enveloped particles Signup and view all the answers

Which type of fusion protein mostly consists of alpha-helices and tends to form trimers?

Class I fusion protein Signup and view all the answers

What type of conformational changes reveal a fusion peptide, which gets inserted into the target cellular membrane during virus-induced membrane fusion?

Conformational changes that reveal a fusion peptide Signup and view all the answers

Where are fusion proteins synthesized, folded, and assembled before undergoing maturation?

Endoplasmic reticulum (ER) Signup and view all the answers

Which type of fusion protein tends to form dimers and involves rearrangement of multimers of protein subunits?

Class II fusion protein Signup and view all the answers

What is the general characteristic of Class II fusion proteins?

Mostly beta-sheets and tend to form dimers Signup and view all the answers

What type of energy is not needed for viral membrane fusion due to the conformation changes that occur?

ATP/metabolic energy Signup and view all the answers

What triggers the rearrangement of multimers of protein subunits in Class II fusion proteins before the final trimer is formed?

pH change Signup and view all the answers

What role do fusion proteins play in viral infection?

They facilitate viral entry into host cells Signup and view all the answers

What is the characteristic conformation of Class I fusion proteins after fusion?

Hairpin conformation Signup and view all the answers

What is the primary structure of Class III fusion proteins?

Combination of alpha-helices and beta-sheets Signup and view all the answers

How are fusion proteins cleaved while transiting from the ER-Golgi to the plasma membrane?

By cellular proteases Signup and view all the answers

What happens to the fusion peptide during virus-induced membrane fusion?

Gets inserted into the target cellular membrane Signup and view all the answers

Which type of fusion proteins can create membrane channels followed by genome egress?

Class III fusion proteins Signup and view all the answers

What is a strategy used by some viruses to pass through the nuclear membrane?

Dissociation of the nuclear membrane during mitosis Signup and view all the answers

What is the primary function of narrow spectrum antivirals?

Be specific to particular viruses Signup and view all the answers

What is the order of genes in coronaviruses based on genome homologies?

Alpha-,beta-, and gammacoronaviruses Signup and view all the answers

What is the structure of coronaviruses?

Studded with trimeric spikes Signup and view all the answers

What is the primary structure of Class III fusion proteins?

Primarily beta-sheet and tends to form dimers Signup and view all the answers

What is the role of hydrophobic proteins in capsids during virus entry?

Create membrane channels followed by genome egress Signup and view all the answers

What is the function of importins in virus entry into the nucleus?

Bind to nuclear localization signals in proteins and import them through the nuclear pore complex Signup and view all the answers

What is the general characteristic of Class II fusion proteins?

Primarily alpha-helical and tends to form trimers Signup and view all the answers

What type of RNA genome do coronaviruses possess?

Linear, single-stranded positive sense RNA genome Signup and view all the answers

What happens to the fusion peptide during virus-induced membrane fusion?

Revealed by conformational changes and inserted into the target cellular membrane Signup and view all the answers

Where are fusion proteins synthesized, folded, and assembled before undergoing maturation?

In the endoplasmic reticulum Signup and view all the answers

Viral Fusion Proteins Quiz

Questions and Answers

Which type of fusion protein tends to form dimers and involves rearrangement of multimers of protein subunits?

What type of conformational changes reveal a fusion peptide, which gets inserted into the target cellular membrane during virus-induced membrane fusion?

Which type of fusion protein tends to be mostly alpha-helical and forms trimers with two distinct conformations?

Where are fusion proteins synthesized, folded, and assembled before undergoing maturation?

Which cellular machinery is often utilized by viruses for transportation to the cytosol?

What is a strategy used by viruses to pass through the nuclear membrane?

What is a strategy for preventing virus entry?

Which type of virus uses the nucleus as a site of replication, taking advantage of the cellular machinery for transcription?

What is the order of genes in coronaviruses based on genome homologies?

What type of RNA genome do coronaviruses possess?

Where are the fusion proteins synthesized, folded, and assembled before undergoing maturation?

What is the function of importins in virus entry into the nucleus?

What is the role of hydrophobic proteins in capsids during virus entry?

What is the primary function of neutralizing antibodies in preventing virus entry?

What is the advantage of narrow spectrum antivirals?

What is the structure of coronaviruses?

Which type of fusion protein mostly consists of alpha-helices and tends to form trimers?

What type of conformational changes reveal a fusion peptide, which gets inserted into the target cellular membrane during virus-induced membrane fusion?

Where are fusion proteins synthesized, folded, and assembled before undergoing maturation?

Which type of fusion protein tends to form dimers and involves rearrangement of multimers of protein subunits?

What is the general characteristic of Class II fusion proteins?

What type of energy is not needed for viral membrane fusion due to the conformation changes that occur?

What triggers the rearrangement of multimers of protein subunits in Class II fusion proteins before the final trimer is formed?

What role do fusion proteins play in viral infection?

What is the characteristic conformation of Class I fusion proteins after fusion?

What is the primary structure of Class III fusion proteins?

How are fusion proteins cleaved while transiting from the ER-Golgi to the plasma membrane?

What happens to the fusion peptide during virus-induced membrane fusion?

Which type of fusion proteins can create membrane channels followed by genome egress?

What is a strategy used by some viruses to pass through the nuclear membrane?

What is the primary function of narrow spectrum antivirals?

What is the order of genes in coronaviruses based on genome homologies?

What is the structure of coronaviruses?

What is the primary structure of Class III fusion proteins?

What is the role of hydrophobic proteins in capsids during virus entry?

What is the function of importins in virus entry into the nucleus?

What is the general characteristic of Class II fusion proteins?

What type of RNA genome do coronaviruses possess?

What happens to the fusion peptide during virus-induced membrane fusion?

Where are fusion proteins synthesized, folded, and assembled before undergoing maturation?

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