Vesiculobullous Disorders and Histologic Features Quiz

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Questions and Answers

What is the term for a fluid filled cavity within or beneath the epidermis?

  • Desmosome
  • Acantholysis
  • Vesicle (correct)
  • Hemidesmosome

Which autoimmune disorder is associated with internal malignancies, including thymoma?

  • Spongiotic dermatitis
  • Lichen planus
  • Lupus erythematosus
  • Pemphigus (correct)

What is the most common type of Pemphigus that involves mucosa and skin, with blisters filled with clear fluid?

  • Erythematosus
  • Foliaceus
  • Vulgaris (correct)
  • Vegetans

Which structure serves as a strong intercellular adhesion structure between cells and is made of 5 proteins including Desmoglein and Desmoplakin?

<p>Desmosome (C)</p> Signup and view all the answers

In which condition do autoantibodies form against Desmoglein 1?

<p>Pemphigus Foliaceus (A)</p> Signup and view all the answers

Which type of bullae is seen in Pemphigus Erythematosus, resembling the lupus malar rash?

<p>Suprabasilar bullae (A)</p> Signup and view all the answers

Which histologic feature is used for the diagnosis of blistering disorders?

<p>Presence/Absence of acantholysis (C)</p> Signup and view all the answers

What is the term for the strong adhesion structures between keratinocytes and the basement membrane?

<p>Hemidesmosome (C)</p> Signup and view all the answers

Which protein is impacted by autoantibodies in Pemphigus Vulgaris?

<p>Desmoglein 3 (C)</p> Signup and view all the answers

What can cause blisters to rupture easily, becoming ulcers especially in the oral cavity in Pemphigus Vulgaris?

<p>Intraepidermal vesicles associated with acantholysis (D)</p> Signup and view all the answers

Which protein is targeted by IgG in Bullous Pemphigoid?

<p>BP180 (BPAG2) (A)</p> Signup and view all the answers

Which type of pemphigus is associated with internal tumors such as lymphoma, thymoma, and carcinomas?

<p>Paraneoplastic Pemphigus (A)</p> Signup and view all the answers

Which genetic mutation/defect is associated with Epidermolysis Bullosa Simplex?

<p>Mutation in Keratin 14 (A)</p> Signup and view all the answers

Which type of porphyria manifests on the skin as subepidermal vesicles?

<p>Porphyria Cutanea Tarda (A)</p> Signup and view all the answers

Which virus causes a painful disease characterized by grouped vesicles on an erythematous base that become pustules and then crust over?

<p>Varicella Zoster virus (VZV) (B)</p> Signup and view all the answers

Which type of pemphigus involves the oral mucosa and skin, with blisters that do not rupture easily and heal without scarring unless infected?

<p>Paraneoplastic Pemphigus (A)</p> Signup and view all the answers

Which type of Epidermolysis Bullosa is characterized by blister formation in the Lamina Lucida?

<p>Junctional (C)</p> Signup and view all the answers

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