Vesiculobullous Disorders and Histologic Features Quiz
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Questions and Answers

What is the term for a fluid filled cavity within or beneath the epidermis?

  • Desmosome
  • Acantholysis
  • Vesicle (correct)
  • Hemidesmosome
  • Which autoimmune disorder is associated with internal malignancies, including thymoma?

  • Spongiotic dermatitis
  • Lichen planus
  • Lupus erythematosus
  • Pemphigus (correct)
  • What is the most common type of Pemphigus that involves mucosa and skin, with blisters filled with clear fluid?

  • Erythematosus
  • Foliaceus
  • Vulgaris (correct)
  • Vegetans
  • Which structure serves as a strong intercellular adhesion structure between cells and is made of 5 proteins including Desmoglein and Desmoplakin?

    <p>Desmosome</p> Signup and view all the answers

    In which condition do autoantibodies form against Desmoglein 1?

    <p>Pemphigus Foliaceus</p> Signup and view all the answers

    Which type of bullae is seen in Pemphigus Erythematosus, resembling the lupus malar rash?

    <p>Suprabasilar bullae</p> Signup and view all the answers

    Which histologic feature is used for the diagnosis of blistering disorders?

    <p>Presence/Absence of acantholysis</p> Signup and view all the answers

    What is the term for the strong adhesion structures between keratinocytes and the basement membrane?

    <p>Hemidesmosome</p> Signup and view all the answers

    Which protein is impacted by autoantibodies in Pemphigus Vulgaris?

    <p>Desmoglein 3</p> Signup and view all the answers

    What can cause blisters to rupture easily, becoming ulcers especially in the oral cavity in Pemphigus Vulgaris?

    <p>Intraepidermal vesicles associated with acantholysis</p> Signup and view all the answers

    Which protein is targeted by IgG in Bullous Pemphigoid?

    <p>BP180 (BPAG2)</p> Signup and view all the answers

    Which type of pemphigus is associated with internal tumors such as lymphoma, thymoma, and carcinomas?

    <p>Paraneoplastic Pemphigus</p> Signup and view all the answers

    Which genetic mutation/defect is associated with Epidermolysis Bullosa Simplex?

    <p>Mutation in Keratin 14</p> Signup and view all the answers

    Which type of porphyria manifests on the skin as subepidermal vesicles?

    <p>Porphyria Cutanea Tarda</p> Signup and view all the answers

    Which virus causes a painful disease characterized by grouped vesicles on an erythematous base that become pustules and then crust over?

    <p>Varicella Zoster virus (VZV)</p> Signup and view all the answers

    Which type of pemphigus involves the oral mucosa and skin, with blisters that do not rupture easily and heal without scarring unless infected?

    <p>Paraneoplastic Pemphigus</p> Signup and view all the answers

    Which type of Epidermolysis Bullosa is characterized by blister formation in the Lamina Lucida?

    <p>Junctional</p> Signup and view all the answers

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