17 Questions
What is the term for a fluid filled cavity within or beneath the epidermis?
Vesicle
Which autoimmune disorder is associated with internal malignancies, including thymoma?
Pemphigus
What is the most common type of Pemphigus that involves mucosa and skin, with blisters filled with clear fluid?
Vulgaris
Which structure serves as a strong intercellular adhesion structure between cells and is made of 5 proteins including Desmoglein and Desmoplakin?
Desmosome
In which condition do autoantibodies form against Desmoglein 1?
Pemphigus Foliaceus
Which type of bullae is seen in Pemphigus Erythematosus, resembling the lupus malar rash?
Suprabasilar bullae
Which histologic feature is used for the diagnosis of blistering disorders?
Presence/Absence of acantholysis
What is the term for the strong adhesion structures between keratinocytes and the basement membrane?
Hemidesmosome
Which protein is impacted by autoantibodies in Pemphigus Vulgaris?
Desmoglein 3
What can cause blisters to rupture easily, becoming ulcers especially in the oral cavity in Pemphigus Vulgaris?
Intraepidermal vesicles associated with acantholysis
Which protein is targeted by IgG in Bullous Pemphigoid?
BP180 (BPAG2)
Which type of pemphigus is associated with internal tumors such as lymphoma, thymoma, and carcinomas?
Paraneoplastic Pemphigus
Which genetic mutation/defect is associated with Epidermolysis Bullosa Simplex?
Mutation in Keratin 14
Which type of porphyria manifests on the skin as subepidermal vesicles?
Porphyria Cutanea Tarda
Which virus causes a painful disease characterized by grouped vesicles on an erythematous base that become pustules and then crust over?
Varicella Zoster virus (VZV)
Which type of pemphigus involves the oral mucosa and skin, with blisters that do not rupture easily and heal without scarring unless infected?
Paraneoplastic Pemphigus
Which type of Epidermolysis Bullosa is characterized by blister formation in the Lamina Lucida?
Junctional
Test your knowledge of vesiculobullous disorders affecting the skin and mucous membranes, along with histologic features used for diagnosis. Learn about the different causes of blisters and the morphological features of keratinocytes.
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