Venlafaxine Prototype Drug Flashcards

Questions and Answers

What is the prototype drug for atypical antidepressants?

Venlafaxine

What is the trade name of Venlafaxine?

Effexor

What is the therapeutic classification of Venlafaxine?

Atypical Antidepressant

What is the pharmacologic classification of Venlafaxine?

Serotonin-Norepinephrine reuptake inhibitor (SNRI) Signup and view all the answers

What are the therapeutic effects and uses of Venlafaxine?

Approved to treat major depression, panic disorder, general anxiety disorder, and social anxiety disorder Signup and view all the answers

What is the mechanism of action (MOA) of Venlafaxine?

Inhibits the presynaptic neuronal reuptake of both norepinephrine and serotonin Signup and view all the answers

What is the route of administration (ROA) of Venlafaxine?

PO Signup and view all the answers

What percentage of Venlafaxine is absorbed by the GI tract?

92% Signup and view all the answers

How is Venlafaxine distributed in the body?

Widely distributed; crosses the placenta; secreted into breast milk; 27% bound to plasma protein Signup and view all the answers

What is the primary metabolism pathway of Venlafaxine?

Metabolized in the liver to desmethylvenlafaxine; an active metabolite; substantial first-pass effect Signup and view all the answers

What is the primary route of excretion for Venlafaxine?

Renal Signup and view all the answers

What is the onset of action for Venlafaxine?

Peak serum level: 5.5 hrs, but the antidepressant action may take 2-3 weeks Signup and view all the answers

What is the duration of action of Venlafaxine?

Half-life: 5-7 hrs (9-11 for the whole active metabolite) Signup and view all the answers

What are the common adverse effects of Venlafaxine?

Nausea, decrease in height and weight, nervousness, insomnia, headache, dizziness; BLACK BOX WARNING Signup and view all the answers

What are the contraindications for using Venlafaxine?

Bipolar or history of mania; hypersensitivity to venlafaxine or an SSRI Signup and view all the answers

What drug interactions should be considered with Venlafaxine?

Drugs that inhibit CYP2D6 may cause venlafaxine serum levels to rise Signup and view all the answers

What is the pregnancy category of Venlafaxine?

C Signup and view all the answers

What are the nursing responsibilities when administering Venlafaxine?

Same as SSRIs; monitor daily weights, take last dose between 4 PM Signup and view all the answers

Study Notes

Venlafaxine Overview

Venlafaxine is the prototype drug for atypical antidepressants.
It is marketed under the trade name Effexor.

Classification

Therapeutically classified as an atypical antidepressant.
Pharmacologically classified as a serotonin-norepinephrine reuptake inhibitor (SNRI).

Indications

Approved for treating major depression, panic disorder, generalized anxiety disorder, and social anxiety disorder.

Mechanism of Action

Works by inhibiting presynaptic neuronal reuptake of norepinephrine and serotonin.

Administration and Absorption

Administered orally (PO).
Approximately 92% is absorbed by the gastrointestinal tract.

Distribution and Metabolism

Widely distributed throughout the body; crosses the placenta and enters breast milk.
27% bound to plasma proteins.
Primarily metabolized in the liver to desmethylvenlafaxine, an active metabolite, with a substantial first-pass effect.

Excretion and Pharmacokinetics

Excreted mainly through the kidneys.
Peak serum level occurs around 5.5 hours after administration.
Antidepressant effects may take 2-3 weeks to manifest.
Half-life is approximately 5-7 hours for venlafaxine and 9-11 hours for its active metabolite.

Adverse Effects

Common side effects include nausea, decreased height and weight, nervousness, insomnia, headaches, and dizziness.
Contains a black box warning due to potential risks.

Contraindications

Not recommended for patients with bipolar disorder or a history of mania.
Contraindicated in individuals with hypersensitivity to venlafaxine or other SSRIs.

Drug Interactions

Concomitant use of drugs that inhibit CYP2D6 may elevate venlafaxine serum levels.

Pregnancy and Nursing Considerations

Classified as pregnancy category C.
Nursing responsibilities mirror those of SSRIs; include monitoring daily weights and scheduling the last dose before 4 PM.

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Description

Test your knowledge on Venlafaxine, the prototype drug for atypical antidepressants. This quiz covers its therapeutic and pharmacologic classifications, as well as its trade name and therapeutic effects. Perfect for students in pharmacology or medical courses.