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Questions and Answers
What is the therapeutic classification of venlafaxine?
What is the main action of venlafaxine?
Inhibits serotonin and norepinephrine reuptake in the CNS.
The usual starting dose for Major Depressive Disorder in adults is _____ mg/day.
75
What are some indications for using venlafaxine?
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Venlafaxine can cause suicidal thoughts as a side effect.
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What should be monitored periodically during venlafaxine therapy?
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What is a nursing implication when administering venlafaxine?
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Patients should take venlafaxine at the same time each day and not _____ doses.
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Study Notes
Classification
- Therapeutic: Antidepressants, antianxiety agents
- Pharmacologic: Selective serotonin/norepinephrine reuptake inhibitors (SSNRIs)
Action
- Inhibits reuptake of serotonin and norepinephrine in the central nervous system (CNS)
- Therapeutic effects include reduced depressive symptoms and anxiety, as well as decreased panic attacks
Dosage/Route
-
Major Depressive Disorder:
- PO (Adults): Start at 75 mg/day in 2-3 divided doses; increase by 75 mg every 4 days, max 375 mg/day
- Extended-release (XR): Start at 75 mg once daily, may increase to 225 mg/day
-
Generalized Anxiety Disorder:
- XR capsules: 75 mg once daily, starting at 37.5 mg for 4-7 days, increasing as needed
-
Social Anxiety Disorder:
- XR capsules: 75 mg once daily
-
Panic Disorder:
- XR capsules: Start at 37.5 mg once daily for 7 days, then may increase
- Hepatic Impairment: Reduce dose by 50% in mild-to-moderate cases
- Renal Impairment: Adjust dose based on creatinine clearance; decrease by 25-50%
Indications
- Major Depressive Disorder
- Generalized Anxiety Disorder (Effexor XR only)
- Social Anxiety Disorder (Effexor XR only)
- Panic Disorder (Effexor XR only)
- Unlabeled Use: Premenstrual Dysphoric Disorder
Side Effects
- CNS: Neuroleptic malignant syndrome, seizures, suicidal thoughts, anxiety, dizziness, headache, insomnia
- EENT: Rhinitis, visual disturbances, tinnitus
- CV: Chest pain, hypertension, tachycardia
- GI: Nausea, vomiting, abdominal pain, weight loss
- GU: Sexual dysfunction, urinary retention
- Derm: Itching, skin rash, ecchymoses
- Neuro: Paresthesia, twitching
- Misc: Serotonin syndrome, chills, yawning
Nursing Implications
- Assess mental status and mood changes; report increased anxiety or insomnia
- Monitor for suicidal tendencies, especially in young adults
- Regularly check blood pressure; adjust therapy if sustained hypertension occurs
- Track nutritional intake and weight; report weight loss
- Watch for signs of serotonin syndrome, especially if other serotonergic drugs are used
- Lab tests: Monitor CBC, liver enzymes, renal function, and electrolytes for abnormalities
Patient/Family Teaching
- Instruct on consistent daily intake; manage missed doses responsibly
- Gradual tapering required after prolonged use to prevent withdrawal
- Encourage reporting of suicidality, worsening depression, agitation, or aggressive behavior
- Advise about potential side effects and the need for immediate communication with healthcare providers
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Description
Test your knowledge of venlafaxine, commonly known as Effexor, with these flashcards. This quiz covers its classification, actions, therapeutic effects, and dosage information. Perfect for students and healthcare professionals looking to reinforce their understanding of this antidepressant.
