Podcast
Questions and Answers
What is a potential risk when combining Duloxetine with dextromethorphan?
What is a potential risk when combining Duloxetine with dextromethorphan?
- Increased metabolism of dextromethorphan
- Risk of serotonin syndrome (correct)
- Enhanced therapeutic effects of Duloxetine
- Reduction of dextromethorphan efficacy
Which of the following accurately describes venlafaxine?
Which of the following accurately describes venlafaxine?
- It primarily acts as a serotonin-norepinephrine reuptake inhibitor (SNRI). (correct)
- It is a selective serotonin reuptake inhibitor (SSRI).
- It is contraindicated in patients with arrhythmias.
- It is used mainly as an anticonvulsant.
What is the maximum recommended daily dose of venlafaxine?
What is the maximum recommended daily dose of venlafaxine?
- 450 mg
- 225 mg (correct)
- 300 mg
- 150 mg
What condition is venlafaxine associated with that might not be considered a side effect?
What condition is venlafaxine associated with that might not be considered a side effect?
Which statement is true regarding desvenlafaxine?
Which statement is true regarding desvenlafaxine?
Study Notes
Duloxetine and Dextromethorphan Interactions
- Duloxetine contraindicated with dextromethorphan due to the risk of serotonin syndrome, a potentially life-threatening condition caused by excessive serotonin levels.
Venlafaxine Overview
- Venlafaxine is classified as a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI), effective for treating depression and anxiety disorders.
- It has an active metabolite known as Desvenlafaxine, which is derived from Venlafaxine's metabolism.
Metabolism Pathways
- Venlafaxine is metabolized primarily by the enzyme CYP2D6 to Desvenlafaxine, followed by further metabolic processes involving CYP3A4.
Side Effects and Risks
- Venlafaxine can increase blood pressure and has been associated with arrhythmias, including ventricular tachycardia and QT interval prolongation.
- Hypertension (HTN) is a notable side effect of Venlafaxine usage, especially at higher doses.
Dosage Information
- Commonly prescribed dosage for Venlafaxine ranges from 75 mg to 150 mg daily.
- The maximum recommended dosage for Venlafaxine is capped at 225 mg.
Additional Uses of SNRI
- Sibutramine, another SNRI, was utilized as an appetite suppressant before being withdrawn from the market in many regions due to health concerns.
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Description
This quiz covers the pharmacological interactions of Duloxetine and Venlafaxine, including their mechanisms, contraindications, and side effects. Understand the risks of serotonin syndrome and the impact of Venlafaxine on blood pressure and cardiovascular health. Test your knowledge about these commonly used antidepressants.
